Chapter 23. Aplastic Anemia, Paroxysmal Nocturnal Hemoglobinuria, and Pure Red Cell Aplasia

  1. Mark A. Crowther MD, MSc, FRCPC Professor Division Director3,4,
  2. Jeff Ginsberg MD, FRCPC Professor5,
  3. Holger J. Schünemann MD, PhD, MSc, FACP, FCCP Professor6,7,
  4. Ralph M. Meyer MD, FRCPC Director Professor8,9 and
  5. Richard Lottenberg MD, FACP Professor10
  1. Shivani Srivastava MD1 and
  2. Richard W. Childs MD2

Published Online: 4 FEB 2009

DOI: 10.1002/9781444300857.ch23

Evidence-Based Hematology

Evidence-Based Hematology

How to Cite

Srivastava, S. and Childs, R. W. (2008) Aplastic Anemia, Paroxysmal Nocturnal Hemoglobinuria, and Pure Red Cell Aplasia, in Evidence-Based Hematology (eds M. A. Crowther, J. Ginsberg, H. J. Schünemann, R. M. Meyer and R. Lottenberg), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444300857.ch23

Editor Information

  1. 3

    Division of Hematology, McMaster University, Hamilton, Ontario, Canada

  2. 4

    St. Joseph's Hospital, Hamilton, Ontario, Canada

  3. 5

    Department of Medicine, McMaster University, Hamilton, Canada

  4. 6

    CLARITY Research Group, Department of Epidemiology, Italian National Cancer Institute Regina Elena, Rome, Italy

  5. 7

    McMaster University, Hamilton, Canada

  6. 8

    National Cancer Institute of Canada, Clinical Trials Group, Edith Eisenhauer Chair in Clinical Cancer Research, Queen's University, Kingston, Ontario, Canada

  7. 9

    Departments of Oncology and Medicine, Queen's University, Kingston, Ontario, Canada

  8. 10

    Division of Hematology/Oncology, Department of Medicine, University of Florida College of Medicine, Gainesville, Florida, USA

Author Information

  1. 1

    Bone Marrow and Stem Cell Transplantation, IU Simon Cancer Center, Indiana University, Indianapolis, Indiana, USA

  2. 2

    Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA

Publication History

  1. Published Online: 4 FEB 2009
  2. Published Print: 27 JUN 2008

ISBN Information

Print ISBN: 9781405157476

Online ISBN: 9781444300857



  • aplastic anemia, paroxysmal nocturnal hemoglobinuria, and pure red cell aplasia;
  • combination of ATG and CSA as first-line treatment;
  • repeating immunosuppression - useful in relapsed or refractory SAA;
  • therapeutic options for patients with SAA refractory;
  • hematopoietic stem cell transplantation for severe aplastic anemia;
  • paroxysmal nocturnal hemoglobinuria (PNH);
  • PNH - rare acquired clonal disorder of hematopoietic stem cells (HSC);
  • allogeneic hematopoietic transplant in patients with PNH;
  • Pure red cell aplasia (PRCA);
  • diagnostic work up for PRCA


This chapter contains sections titled:

  • Literature search

  • Exclusion criteria

  • Inclusion criteria

  • Aplastic anemia

  • Paroxysmal nocturnal hemoglobinuria

  • Pure red cell aplasia

  • References