Chapter 24. Acquired Anemias: Iron Deficiency, Cobalamin Deficiency, and Autoimmune Hemolytic Anemia

  1. Mark A. Crowther MD, MSc, FRCPC Professor Division Director3,4,
  2. Jeff Ginsberg MD, FRCPC Professor5,
  3. Holger J. Schünemann MD, PhD, MSc, FACP, FCCP Professor6,7,
  4. Ralph M. Meyer MD, FRCPC Director Professor8,9 and
  5. Richard Lottenberg MD, FACP Professor10
  1. Marc S. Zumberg MD1 and
  2. Marc J. Kahn MD2

Published Online: 4 FEB 2009

DOI: 10.1002/9781444300857.ch24

Evidence-Based Hematology

Evidence-Based Hematology

How to Cite

Zumberg, M. S. and Kahn, M. J. (2008) Acquired Anemias: Iron Deficiency, Cobalamin Deficiency, and Autoimmune Hemolytic Anemia, in Evidence-Based Hematology (eds M. A. Crowther, J. Ginsberg, H. J. Schünemann, R. M. Meyer and R. Lottenberg), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444300857.ch24

Editor Information

  1. 3

    Division of Hematology, McMaster University, Hamilton, Ontario, Canada

  2. 4

    St. Joseph's Hospital, Hamilton, Ontario, Canada

  3. 5

    Department of Medicine, McMaster University, Hamilton, Canada

  4. 6

    CLARITY Research Group, Department of Epidemiology, Italian National Cancer Institute Regina Elena, Rome, Italy

  5. 7

    McMaster University, Hamilton, Canada

  6. 8

    National Cancer Institute of Canada, Clinical Trials Group, Edith Eisenhauer Chair in Clinical Cancer Research, Queen's University, Kingston, Ontario, Canada

  7. 9

    Departments of Oncology and Medicine, Queen's University, Kingston, Ontario, Canada

  8. 10

    Division of Hematology/Oncology, Department of Medicine, University of Florida College of Medicine, Gainesville, Florida, USA

Author Information

  1. 1

    Department of Medicine, Division of Hematology/Oncology, University of Florida, Gainesville, Florida, USA

  2. 2

    School of Medicine, Tulane University School of Medicine, New Orleans, Louisiana, USA

Publication History

  1. Published Online: 4 FEB 2009
  2. Published Print: 27 JUN 2008

ISBN Information

Print ISBN: 9781405157476

Online ISBN: 9781444300857



  • acquired anemias;
  • grading evidence and recommendations;
  • iron deficiency anemia;
  • intravenous iron to oral iron salts in patient populations;
  • Cobalamin (B12) deficiency;
  • role of measurement of homocysteine and methylmalonic acid in assessment;
  • autoimmune hemolytic anemia (AIHA);
  • oral cobalamin replacement for patients with cobalamin deficiency;
  • role of rituximab in WAIHA


This chapter contains sections titled:

  • Literature-search criteria

  • Grading evidence and recommendations

  • Iron deficiency anemia

  • Summary

  • Cobalamin (B12) deficiency

  • Autoimmune hemolytic anemia (AIHA)

  • References