Chapter 25. Immune Thrombocytopenic Purpura

  1. Mark A. Crowther MD, MSc, FRCPC Professor Division Director4,5,
  2. Jeff Ginsberg MD, FRCPC Professor6,
  3. Holger J. Schünemann MD, PhD, MSc, FACP, FCCP Professor7,8,
  4. Ralph M. Meyer MD, FRCPC Director Professor9,10 and
  5. Richard Lottenberg MD, FACP Professor11
  1. James N. George MD1,
  2. Sara K. Vesely PhD2 and
  3. George R. Buchanan MD3

Published Online: 4 FEB 2009

DOI: 10.1002/9781444300857.ch25

Evidence-Based Hematology

Evidence-Based Hematology

How to Cite

George, J. N., Vesely, S. K. and Buchanan, G. R. (2008) Immune Thrombocytopenic Purpura, in Evidence-Based Hematology (eds M. A. Crowther, J. Ginsberg, H. J. Schünemann, R. M. Meyer and R. Lottenberg), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444300857.ch25

Editor Information

  1. 4

    Division of Hematology, McMaster University, Hamilton, Ontario, Canada

  2. 5

    St. Joseph's Hospital, Hamilton, Ontario, Canada

  3. 6

    Department of Medicine, McMaster University, Hamilton, Canada

  4. 7

    CLARITY Research Group, Department of Epidemiology, Italian National Cancer Institute Regina Elena, Rome, Italy

  5. 8

    McMaster University, Hamilton, Canada

  6. 9

    National Cancer Institute of Canada, Clinical Trials Group, Edith Eisenhauer Chair in Clinical Cancer Research, Queen's University, Kingston, Ontario, Canada

  7. 10

    Departments of Oncology and Medicine, Queen's University, Kingston, Ontario, Canada

  8. 11

    Division of Hematology/Oncology, Department of Medicine, University of Florida College of Medicine, Gainesville, Florida, USA

Author Information

  1. 1

    Hematology–Oncology Section, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA

  2. 2

    Department of Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA

  3. 3

    Division of Hematology-Oncology, Department of Pediatrics, University of Texas, Southwestern Medical Center at Dallas, Dallas, Texas, USA

Publication History

  1. Published Online: 4 FEB 2009
  2. Published Print: 27 JUN 2008

ISBN Information

Print ISBN: 9781405157476

Online ISBN: 9781444300857



  • immune thrombocytopenic purpura (ITP);
  • clinical questions, evidence, and recommendations;
  • benign hematologic disorders;
  • initial management of children with ITP;
  • management of adults with ITP;
  • chronic ITP management;
  • management of persistent ITP - splenectomy;
  • persistent ITP - investigational treatments


This chapter contains sections titled:

  • Introduction

  • Definition

  • Pathogenesis

  • Diagnosis

  • Clinical course

  • Management

  • Conclusion

  • References