Chapter 27. Hypereosinophilia: Primary and Secondary

  1. Mark A. Crowther MD, MSc, FRCPC Professor Division Director4,5,
  2. Jeff Ginsberg MD, FRCPC Professor6,
  3. Holger J. Schünemann MD, PhD, MSc, FACP, FCCP Professor7,8,
  4. Ralph M. Meyer MD, FRCPC Director Professor9,10 and
  5. Richard Lottenberg MD, FACP Professor11
  1. Florence Roufosse MD, PhD1,
  2. Michel Goldman MD, PhD2 and
  3. Elie Cogan MD, PhD3

Published Online: 4 FEB 2009

DOI: 10.1002/9781444300857.ch27

Evidence-Based Hematology

Evidence-Based Hematology

How to Cite

Roufosse, F., Goldman, M. and Cogan, E. (2008) Hypereosinophilia: Primary and Secondary, in Evidence-Based Hematology (eds M. A. Crowther, J. Ginsberg, H. J. Schünemann, R. M. Meyer and R. Lottenberg), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444300857.ch27

Editor Information

  1. 4

    Division of Hematology, McMaster University, Hamilton, Ontario, Canada

  2. 5

    St. Joseph's Hospital, Hamilton, Ontario, Canada

  3. 6

    Department of Medicine, McMaster University, Hamilton, Canada

  4. 7

    CLARITY Research Group, Department of Epidemiology, Italian National Cancer Institute Regina Elena, Rome, Italy

  5. 8

    McMaster University, Hamilton, Canada

  6. 9

    National Cancer Institute of Canada, Clinical Trials Group, Edith Eisenhauer Chair in Clinical Cancer Research, Queen's University, Kingston, Ontario, Canada

  7. 10

    Departments of Oncology and Medicine, Queen's University, Kingston, Ontario, Canada

  8. 11

    Division of Hematology/Oncology, Department of Medicine, University of Florida College of Medicine, Gainesville, Florida, USA

Author Information

  1. 1

    Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles (ULB), Institute for Medical Immunology, Université Libre de Bruxelles (ULB), Gosselies, Brussels, Belgium

  2. 2

    Institute for Medical Immunology, Université Libre de Bruxelles, Charleroi-Gosselies, Belgium

  3. 3

    Department of Internal Medicine, Erasme Hospital, Brussels, Université Libre de Bruxelles (ULB), Belgium

Publication History

  1. Published Online: 4 FEB 2009
  2. Published Print: 27 JUN 2008

ISBN Information

Print ISBN: 9781405157476

Online ISBN: 9781444300857



  • hypereosinophilia;
  • diagnostic workup and therapy for hypereosinophilic syndromes;
  • diagnostic testing in patients with hypereosinophilic syndrome;
  • therapy for F/P-associated HES;
  • therapy for F/P-negative HES?;
  • suggested algorithm for management of patients with definite HES;
  • corticosteroids - initiated as first-line therapy


This chapter contains sections titled:

  • Background

  • Definition and characteristics of HES

  • Literature-search strategy

  • What diagnostic testing is indicated in patients with hypereosinophilic syndrome?

  • What is the therapy for F/P-associated HES?

  • What is the therapy for F/P-negative HES?

  • References