Chapter 28. Porphyrias

  1. Mark A. Crowther MD, MSc, FRCPC Professor Division Director3,4,
  2. Jeff Ginsberg MD, FRCPC Professor5,
  3. Holger J. Schünemann MD, PhD, MSc, FACP, FCCP Professor6,7,
  4. Ralph M. Meyer MD, FRCPC Director Professor8,9 and
  5. Richard Lottenberg MD, FACP Professor10
  1. Gagan Sood MD1 and
  2. Karl E. Anderson MD2

Published Online: 4 FEB 2009

DOI: 10.1002/9781444300857.ch28

Evidence-Based Hematology

Evidence-Based Hematology

How to Cite

Sood, G. and Anderson, K. E. (2008) Porphyrias, in Evidence-Based Hematology (eds M. A. Crowther, J. Ginsberg, H. J. Schünemann, R. M. Meyer and R. Lottenberg), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444300857.ch28

Editor Information

  1. 3

    Division of Hematology, McMaster University, Hamilton, Ontario, Canada

  2. 4

    St. Joseph's Hospital, Hamilton, Ontario, Canada

  3. 5

    Department of Medicine, McMaster University, Hamilton, Canada

  4. 6

    CLARITY Research Group, Department of Epidemiology, Italian National Cancer Institute Regina Elena, Rome, Italy

  5. 7

    McMaster University, Hamilton, Canada

  6. 8

    National Cancer Institute of Canada, Clinical Trials Group, Edith Eisenhauer Chair in Clinical Cancer Research, Queen's University, Kingston, Ontario, Canada

  7. 9

    Departments of Oncology and Medicine, Queen's University, Kingston, Ontario, Canada

  8. 10

    Division of Hematology/Oncology, Department of Medicine, University of Florida College of Medicine, Gainesville, Florida, USA

Author Information

  1. 1

    Division of Gastroenterology and Hepatology, Department of Internal Medicine, The University of Texas Medical Branch, Galveston, Texas, USA

  2. 2

    Departments of Preventive Medicine and Community Health, Internal Medicine and Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas, USA

Publication History

  1. Published Online: 4 FEB 2009
  2. Published Print: 27 JUN 2008

ISBN Information

Print ISBN: 9781405157476

Online ISBN: 9781444300857



  • porphyrias from enzymatic defects in heme biosynthetic pathway;
  • porphyrias diagnosis;
  • erythropoietic protoporphyria;
  • porphyrias causing blistering cutaneous porphyrias;
  • acute porphyrias treatment;
  • carbohydrate loading;
  • early detection of hepatocellular carcinoma;
  • supportive, symptomatic, and other treatment;
  • protoporphyric hepatopathy treatment


This chapter contains sections titled:

  • Diagnosis of porphyrias

  • Treatment of acute porphyrias

  • Treatment of congenital erythropoietic porphyria

  • Treatment of porphyria cutanea tarda

  • Treatment of erythropoietic protoporphyria

  • References