Chapter 29. Membrane and Enzyme Abnormalities of the Erythrocyte

  1. Mark A. Crowther MD, MSc, FRCPC Professor Division Director3,4,
  2. Jeff Ginsberg MD, FRCPC Professor5,
  3. Holger J. Schünemann MD, PhD, MSc, FACP, FCCP Professor6,7,
  4. Ralph M. Meyer MD, FRCPC Director Professor8,9 and
  5. Richard Lottenberg MD, FACP Professor10
  1. Patrick G. Gallagher MD, FAAP1 and
  2. Ernest Beutler MD2

Published Online: 4 FEB 2009

DOI: 10.1002/9781444300857.ch29

Evidence-Based Hematology

Evidence-Based Hematology

How to Cite

Gallagher, P. G. and Beutler, E. (2008) Membrane and Enzyme Abnormalities of the Erythrocyte, in Evidence-Based Hematology (eds M. A. Crowther, J. Ginsberg, H. J. Schünemann, R. M. Meyer and R. Lottenberg), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444300857.ch29

Editor Information

  1. 3

    Division of Hematology, McMaster University, Hamilton, Ontario, Canada

  2. 4

    St. Joseph's Hospital, Hamilton, Ontario, Canada

  3. 5

    Department of Medicine, McMaster University, Hamilton, Canada

  4. 6

    CLARITY Research Group, Department of Epidemiology, Italian National Cancer Institute Regina Elena, Rome, Italy

  5. 7

    McMaster University, Hamilton, Canada

  6. 8

    National Cancer Institute of Canada, Clinical Trials Group, Edith Eisenhauer Chair in Clinical Cancer Research, Queen's University, Kingston, Ontario, Canada

  7. 9

    Departments of Oncology and Medicine, Queen's University, Kingston, Ontario, Canada

  8. 10

    Division of Hematology/Oncology, Department of Medicine, University of Florida College of Medicine, Gainesville, Florida, USA

Author Information

  1. 1

    Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut, USA

  2. 2

    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, USA

Publication History

  1. Published Online: 4 FEB 2009
  2. Published Print: 27 JUN 2008

ISBN Information

Print ISBN: 9781405157476

Online ISBN: 9781444300857



  • membrane and enzyme abnormalities;
  • disorders with spherocytes on blood film;
  • autohemolysis and other tests;
  • erythrocyte indices;
  • osmotic fragility (OF) test;
  • molecular studies;
  • fresh OF test and circulating spherocytes, erythrocytes detection;
  • erythrocyte enzyme deficiencies;
  • splenectomy in hereditary spherocytosis


This chapter contains sections titled:

  • Introduction

  • What is the best way to diagnose hereditary spherocytosis?

  • What is the best approach to a patient with a suspected erythrocyte enzyme defect?

  • Role of splenectomy in hereditary spherocytosis

  • Postsplenectomy Management

  • References