Chapter 3. Interpreting Results in Clinical Research: Overview of Measures of Effect, Measures of Precision, and Measures of Diagnostic Accuracy for Clinicians and Researchers

  1. Mark A. Crowther MD, MSc, FRCPC Professor Division Director4,5,
  2. Jeff Ginsberg MD, FRCPC Professor6,
  3. Holger J. Schünemann MD, PhD, MSc, FACP, FCCP Professor7,8,
  4. Ralph M. Meyer MD, FRCPC Director Professor9,10 and
  5. Richard Lottenberg MD, FACP Professor11
  1. Marcello Di Nisio MD, PhD1,
  2. Harry R. Büller MD2 and
  3. Patrick M. M. Bossuyt PhD3

Published Online: 4 FEB 2009

DOI: 10.1002/9781444300857.ch3

Evidence-Based Hematology

Evidence-Based Hematology

How to Cite

Di Nisio, M., Büller, H. R. and Bossuyt, P. M. M. (2009) Interpreting Results in Clinical Research: Overview of Measures of Effect, Measures of Precision, and Measures of Diagnostic Accuracy for Clinicians and Researchers, in Evidence-Based Hematology (eds M. A. Crowther, J. Ginsberg, H. J. Schünemann, R. M. Meyer and R. Lottenberg), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444300857.ch3

Editor Information

  1. 4

    Division of Hematology, McMaster University, Hamilton, Ontario, Canada

  2. 5

    St. Joseph's Hospital, Hamilton, Ontario, Canada

  3. 6

    Department of Medicine, McMaster University, Hamilton, Canada

  4. 7

    CLARITY Research Group, Department of Epidemiology, Italian National Cancer Institute Regina Elena, Rome, Italy

  5. 8

    McMaster University, Hamilton, Canada

  6. 9

    National Cancer Institute of Canada, Clinical Trials Group, Edith Eisenhauer Chair in Clinical Cancer Research, Queen's University, Kingston, Ontario, Canada

  7. 10

    Departments of Oncology and Medicine, Queen's University, Kingston, Ontario, Canada

  8. 11

    Division of Hematology/Oncology, Department of Medicine, University of Florida College of Medicine, Gainesville, Florida, USA

Author Information

  1. 1

    Department of Medicine and Aging, School of Medicine, and Aging Research Center, Ce.S.I., “Gabriele D'Annunzio”, University Foundation, Chieti-Pescara, Italy

  2. 2

    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

  3. 3

    Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

Publication History

  1. Published Online: 4 FEB 2009
  2. Published Print: 27 JUN 2008

ISBN Information

Print ISBN: 9781405157476

Online ISBN: 9781444300857

SEARCH

Keywords:

  • interpreting results in clinical research;
  • measures of precision;
  • diagnostic accuracy measures;
  • number needed to treat (NNT) or the number needed to harm (NNH);
  • test and treatment thresholds;
  • test accuracy - surrogate for patient outcomes;
  • sensitivity, specificity, and predictive values of diagnostic tests;
  • likelihood ratios contrasting proportions of patients with and without target disorder

Summary

This chapter contains sections titled:

  • Introduction

  • Measures of effect

  • Measures of diagnostic accuracy

  • Conclusions

  • References