Chapter 40. Primary Central Nervous System Lymphoma

  1. Mark A. Crowther MD, MSc, FRCPC Professor Division Director2,3,
  2. Jeff Ginsberg MD, FRCPC Professor4,
  3. Holger J. Schünemann MD, PhD, MSc, FACP, FCCP Professor5,6,
  4. Ralph M. Meyer MD, FRCPC Director Professor7,8 and
  5. Richard Lottenberg MD, FACP Professor9
  1. Tamara Shenkier MDCM, FRCPC

Published Online: 4 FEB 2009

DOI: 10.1002/9781444300857.ch40

Evidence-Based Hematology

Evidence-Based Hematology

How to Cite

Shenkier, T. (2008) Primary Central Nervous System Lymphoma, in Evidence-Based Hematology (eds M. A. Crowther, J. Ginsberg, H. J. Schünemann, R. M. Meyer and R. Lottenberg), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444300857.ch40

Editor Information

  1. 2

    Division of Hematology, McMaster University, Hamilton, Ontario, Canada

  2. 3

    St. Joseph's Hospital, Hamilton, Ontario, Canada

  3. 4

    Department of Medicine, McMaster University, Hamilton, Canada

  4. 5

    CLARITY Research Group, Department of Epidemiology, Italian National Cancer Institute Regina Elena, Rome, Italy

  5. 6

    McMaster University, Hamilton, Canada

  6. 7

    National Cancer Institute of Canada, Clinical Trials Group, Edith Eisenhauer Chair in Clinical Cancer Research, Queen's University, Kingston, Ontario, Canada

  7. 8

    Departments of Oncology and Medicine, Queen's University, Kingston, Ontario, Canada

  8. 9

    Division of Hematology/Oncology, Department of Medicine, University of Florida College of Medicine, Gainesville, Florida, USA

Author Information

  1. Department of Medical Oncology, University of British Columbia, British Columbia Cancer Agency, Vancouver, British Columbia, Canada

Publication History

  1. Published Online: 4 FEB 2009
  2. Published Print: 27 JUN 2008

ISBN Information

Print ISBN: 9781405157476

Online ISBN: 9781444300857



  • Primary central nervous system lymphoma (PCNSL) - extranodal non-Hodgkin's lymphoma (NHL);
  • wholebrain irradiation (WBXRT) - mainstay of care;
  • BMPD chemotherapy;
  • methotrexate-based CMT;
  • MSKCC/RTOG regime of methotrexate;
  • cytarabine administered following WBXRT;
  • cytarabine in multiagent protocols;
  • International Extranodal Lymphoma Study Group (IELSG);
  • PubMed MEDLINE database at National Library of Medicine


This chapter contains sections titled:

  • Introduction

  • Questions

  • Literature-search strategy and inclusions

  • Summary of literature extraction

  • References