Chapter 49. Management of Patients with Polycythemia Vera

  1. Mark A. Crowther MD, MSc, FRCPC Professor Division Director4,5,
  2. Jeff Ginsberg MD, FRCPC Professor6,
  3. Holger J. Schünemann MD, PhD, MSc, FACP, FCCP Professor7,8,
  4. Ralph M. Meyer MD, FRCPC Director Professor9,10 and
  5. Richard Lottenberg MD, FACP Professor11
  1. Guido Finazzi MD Director1,
  2. Roberto Marchioli MD2 and
  3. Tiziano Barbui MD3

Published Online: 4 FEB 2009

DOI: 10.1002/9781444300857.ch49

Evidence-Based Hematology

Evidence-Based Hematology

How to Cite

Finazzi, G., Marchioli, R. and Barbui, T. (2008) Management of Patients with Polycythemia Vera, in Evidence-Based Hematology (eds M. A. Crowther, J. Ginsberg, H. J. Schünemann, R. M. Meyer and R. Lottenberg), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444300857.ch49

Editor Information

  1. 4

    Division of Hematology, McMaster University, Hamilton, Ontario, Canada

  2. 5

    St. Joseph's Hospital, Hamilton, Ontario, Canada

  3. 6

    Department of Medicine, McMaster University, Hamilton, Canada

  4. 7

    CLARITY Research Group, Department of Epidemiology, Italian National Cancer Institute Regina Elena, Rome, Italy

  5. 8

    McMaster University, Hamilton, Canada

  6. 9

    National Cancer Institute of Canada, Clinical Trials Group, Edith Eisenhauer Chair in Clinical Cancer Research, Queen's University, Kingston, Ontario, Canada

  7. 10

    Departments of Oncology and Medicine, Queen's University, Kingston, Ontario, Canada

  8. 11

    Division of Hematology/Oncology, Department of Medicine, University of Florida College of Medicine, Gainesville, Florida, USA

Author Information

  1. 1

    Transfusion Medicine and Haemostasis and Thrombosis Services, Ospedali Riuniti, Bergamo, Italy

  2. 2

    Laboratory of Clinical Epidemiology of Cardiovascular Disease, Department of Clinical Pharmacology and Epidemiology, Consorzio Mario Negri Sud, Santa Maria Imbaro, Italy

  3. 3

    Department of Hematology-Oncology, Ospedali Riuniti di Bergamo, Bergamo (Bg), Italy

Publication History

  1. Published Online: 4 FEB 2009
  2. Published Print: 27 JUN 2008

ISBN Information

Print ISBN: 9781405157476

Online ISBN: 9781444300857



  • Polycythemia vera (PV) and chronic myeloproliferative disorder (MPD);
  • European Collaboration on Low-dose Aspirin in Polycythemia (ECLAP);
  • Polycythemia Vera Study Group (PVSG);
  • MEDLINE, PubMed, CANCERLIT, Cochrane Library, and EMBASE;
  • therapy for high-risk patients;
  • therapy for low-risk patients;
  • myelosuppressive therapy and reduction of leukemogenesis


This chapter contains sections titled:

  • Introduction

  • Questions

  • Literature-search strategy and inclusion

  • How should patients be stratified into risk categories?

  • Which therapy should low-risk patients receive?

  • Which therapy should high-risk patients receive?

  • When myelosuppressive therapy is required, how can the risk of leukemogenesis be reduced?

  • References