Chapter 5. Applying EBM in Clinical Practice

  1. Mark A. Crowther MD, MSc, FRCPC Professor Division Director3,4,
  2. Jeff Ginsberg MD, FRCPC Professor5,
  3. Holger J. Schünemann MD, PhD, MSc, FACP, FCCP Professor6,7,
  4. Ralph M. Meyer MD, FRCPC Director Professor8,9 and
  5. Richard Lottenberg MD, FACP Professor10
  1. Alessandro Squizzato MD1,
  2. Walter Ageno MD1 and
  3. Davide Imberti MD2

Published Online: 4 FEB 2009

DOI: 10.1002/9781444300857.ch5

Evidence-Based Hematology

Evidence-Based Hematology

How to Cite

Squizzato, A., Ageno, W. and Imberti, D. (2008) Applying EBM in Clinical Practice, in Evidence-Based Hematology (eds M. A. Crowther, J. Ginsberg, H. J. Schünemann, R. M. Meyer and R. Lottenberg), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444300857.ch5

Editor Information

  1. 3

    Division of Hematology, McMaster University, Hamilton, Ontario, Canada

  2. 4

    St. Joseph's Hospital, Hamilton, Ontario, Canada

  3. 5

    Department of Medicine, McMaster University, Hamilton, Canada

  4. 6

    CLARITY Research Group, Department of Epidemiology, Italian National Cancer Institute Regina Elena, Rome, Italy

  5. 7

    McMaster University, Hamilton, Canada

  6. 8

    National Cancer Institute of Canada, Clinical Trials Group, Edith Eisenhauer Chair in Clinical Cancer Research, Queen's University, Kingston, Ontario, Canada

  7. 9

    Departments of Oncology and Medicine, Queen's University, Kingston, Ontario, Canada

  8. 10

    Division of Hematology/Oncology, Department of Medicine, University of Florida College of Medicine, Gainesville, Florida, USA

Author Information

  1. 1

    Department of Clinical Medicine, University of Insubria, Varese, Italy

  2. 2

    Head of Thrombosis Center, Emergency Department, Hospital of Piacenza, Piacenza, Italy

Publication History

  1. Published Online: 4 FEB 2009
  2. Published Print: 27 JUN 2008

ISBN Information

Print ISBN: 9781405157476

Online ISBN: 9781444300857



  • applying EBM in clinical practice;
  • MEDLINE search and systematic review evaluating efficacy and safety of UFH or LMWH in VTE;
  • applying results of systematic review in clinical practice;
  • applying results of randomized controlled trial in clinical practice;
  • evidence-based medicine in absence of high-quality evidence;
  • choosing best diagnostic strategy;
  • finding and appraising evidence;
  • resolution of scenario


This chapter contains sections titled:

  • Introduction

  • Applying an evidence-based guideline in clinical practice

  • Applying the results of a systematic review in clinical practice

  • Applying the results of a randomized controlled trial in clinical practice

  • Practice of evidence-based medicine in the absence of high-quality evidence

  • Choosing the best diagnostic strategy

  • Conclusion

  • References