Chapter 30. Acute Severe Ulcerative Colitis

  1. Tony C. K. Tham MD, FRCP, FRCPI Consultant Gastroenterologist Head of School of Medicine2,3,
  2. John S. A. Collins MD Consultant Gastroenterologist4 and
  3. Roy M. Soetikno MD, MS Chief Associate Professor5,6
  1. Subrata Ghosh MD, FRCP, FRCP(E) Professor of Gastroenterology

Published Online: 9 FEB 2009

DOI: 10.1002/9781444303292.ch30

Gastrointestinal Emergencies, Second Edition

Gastrointestinal Emergencies, Second Edition

How to Cite

Ghosh, S. (2008) Acute Severe Ulcerative Colitis, in Gastrointestinal Emergencies, Second Edition (eds T. C. K. Tham, J. S. A. Collins and R. M. Soetikno), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444303292.ch30

Editor Information

  1. 2

    The Ulster Hospital, Dundonald, Belfast, Northern Ireland, UK

  2. 3

    Northern Ireland deanery, UK

  3. 4

    Royal Victoria Hospital, Belfast, Northern Ireland, UK

  4. 5

    GI Section, VA Palo Alto Health Care System, USA

  5. 6

    Stanford University, USA

Author Information

  1. Imperial College London, Hammersmith Hospital, London, UK

Publication History

  1. Published Online: 9 FEB 2009
  2. Published Print: 28 NOV 2008

ISBN Information

Print ISBN: 9781405146340

Online ISBN: 9781444303292



  • acute severe ulcerative colitis;
  • principles of management;
  • monitoring regimen in acute severe ulcerative colitis;
  • managing intravenous steroid refractory acute severe colitis;
  • salvage therapy in intravenous steroid-refractory patients;
  • chimeric anti-TNF antibody infliximab in ulcerative colitis;
  • leukocyte apheresis;
  • monoclonal humanized antibody to interleukin-2 receptor (CD25, IL-2R);
  • management of fluid and electrolyte disturbances


This chapter contains sections titled:

  • Introduction

  • Acute severe Crohn's colitis

  • Principles of management

  • Conclusion

  • References