Chapter 11. Exercise, Inflammation, and Metabolism

  1. Ronald J. Maughan PhD
  1. Bente K. Pedersen MD, DMSc

Published Online: 10 FEB 2009

DOI: 10.1002/9781444303315.ch11

Olympic Textbook of Science in Sport

Olympic Textbook of Science in Sport

How to Cite

Pedersen, B. K. (2008) Exercise, Inflammation, and Metabolism, in Olympic Textbook of Science in Sport (ed R. J. Maughan), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444303315.ch11

Editor Information

  1. School of Sport and Exercise Sciences, Loughborough University, Loughborough, UK

Author Information

  1. Centre of Inflammation and Metabolism, Rigshospitalet 7641, Copenhagen, Denmark

Publication History

  1. Published Online: 10 FEB 2009
  2. Published Print: 28 NOV 2008

ISBN Information

Print ISBN: 9781405156387

Online ISBN: 9781444303315



  • chronic diseases linked with low-grade systemic inflammation;
  • insulin resistance;
  • type 2 diabetes;
  • coronary heart disease;
  • players in chronic low-grade inflammation;
  • searching for the exercise factor;
  • systemic cytokine response to exercise;
  • IL-6 derived from working muscles during concentric exercise


This chapter contains sections titled:

  • Chronic diseases linked with low-grade systemic inflammation

  • Evidence for prescribing exercise as therapy in chronic diseases

  • The players in chronic low-grade inflammation and its link with chronic disease

  • The systemic cytokine response to exercise

  • Searching for the exercise factor

  • IL-6 and its receptor

  • Exercise and IL-6

  • IL-6 is derived from working muscle during concentric exercise

  • Intracellular signaling

  • Role of carbohydrate and glycogen

  • Role of epinephrine and lactate

  • IL-6 production from trained and untrained muscle

  • Sources of contraction-induced production of IL-6

  • Exercise and IL-6 receptors

  • Inflammation, insulin resistance, and atherosclerosis

  • The anti-inflammatory effects of IL-6

  • The anti-inflammatory effects of acute exercise

  • Conclusion

  • Acknowledgements

  • References