Chapter 1. Platelet Physiology and the Role of the Platelet in Ischemic Heart Disease

  1. Stephen D. Wiviott MD Assistant Professor Investigator
  1. Robert F. Storey BSc, BM, MRCP, DM

Published Online: 19 FEB 2009

DOI: 10.1002/9781444303339.ch1

Antiplatelet Therapy In Ischemic Heart Disease

Antiplatelet Therapy In Ischemic Heart Disease

How to Cite

Storey, R. F. (2008) Platelet Physiology and the Role of the Platelet in Ischemic Heart Disease, in Antiplatelet Therapy In Ischemic Heart Disease (ed S. D. Wiviott), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444303339.ch1

Editor Information

  1. Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, TIMI Study Group, Boston, MA, USA

Author Information

  1. Cardiovascular Research Unit, School of Medicine and Biomedical Sciences, University of Sheffield, UK

Publication History

  1. Published Online: 19 FEB 2009
  2. Published Print: 28 NOV 2008

Book Series:

  1. The AHA Clinical Series

Book Series Editors:

  1. Elliott Antman MD, FAHA

Series Editor Information

  1. Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, TIMI Study Group, Boston, MA, USA

ISBN Information

Print ISBN: 9781405176262

Online ISBN: 9781444303339

SEARCH

Keywords:

  • platelet physiology and platelet in ischemic heart disease;
  • blood platelets – equipped for action;
  • platelet activation mechanism and associated functional responses;
  • platelet adhesion and thrombus formation initiation;
  • role of platelet in coronary atherothrombosis;
  • inflammatory responses of platelets;
  • α-Granule secretion consequent to platelet activation leading pro-inflammatory process;
  • platelets and role in hemostasis and physiological responses to vascular injury

Summary

This chapter contains sections titled:

  • Blood platelets – equipped for action

  • The platelet glycoprotein IIb/IIIa complex

  • Platelet adhesion and initiation of thrombus formation

  • Platelet P2 receptors

  • Platelet protease-activated receptors (PARs) and thrombin

  • The arachidonic acid pathway and thromboxane A2

  • Receptor pathways that inhibit platelet activation

  • Platelet procoagulant activity

  • Inflammatory responses of platelets

  • The role of the platelet in coronary atherothrombosis

  • Conclusion

  • References