Chapter 4. Aspirin Response Variability and Resistance

  1. Stephen D. Wiviott MD Assistant Professor Investigator
  1. Wai-Hong Chen MBBS, FACC, FAHA1 and
  2. Daniel I. Simon MD2

Published Online: 19 FEB 2009

DOI: 10.1002/9781444303339.ch4

Antiplatelet Therapy In Ischemic Heart Disease

Antiplatelet Therapy In Ischemic Heart Disease

How to Cite

Chen, W.-H. and Simon, D. I. (2008) Aspirin Response Variability and Resistance, in Antiplatelet Therapy In Ischemic Heart Disease (ed S. D. Wiviott), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444303339.ch4

Editor Information

  1. Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, TIMI Study Group, Boston, MA, USA

Author Information

  1. 1

    Division of Cardiology, Department of Medicine, The University of Hong Kong, Queen Mary Hospital Hong Kong, China

  2. 2

    Harrington-McLanghlin Heart & Vascular Institute, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA

Publication History

  1. Published Online: 19 FEB 2009
  2. Published Print: 28 NOV 2008

Book Series:

  1. The AHA Clinical Series

Book Series Editors:

  1. Elliott Antman MD, FAHA

Series Editor Information

  1. Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, TIMI Study Group, Boston, MA, USA

ISBN Information

Print ISBN: 9781405176262

Online ISBN: 9781444303339

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Keywords:

  • pharmacology of oral antiplatelet agents;
  • antiplatelet effects of aspirin;
  • aspirin resistance mechanisms;
  • prevalence of aspirin resistance;
  • aspirin response and clinical outcomes;
  • Ultegra Rapid Platelet Function Assay-P2Y12;
  • interindividual variability in platelet inhibitory responsiveness to aspirin

Summary

This chapter contains sections titled:

  • Introduction

  • Definition(s) of aspirin resistance

  • Mechanisms of aspirin resistance

  • Prevalence of aspirin resistance

  • Clinical relevance of aspirin resistance

  • Conclusions and future directions

  • References