Chapter 12. Renal Replacement Therapy in Acute Kidney Injury

  1. Donald A. Molony MD3,4 and
  2. Jonathan C. Craig MD, PhD5,6
  1. Steven D. Weisbord MD, MSc1,2 and
  2. Paul M. Palevsky MD1,2

Published Online: 4 MAR 2009

DOI: 10.1002/9781444303391.ch12

Evidence-Based Nephrology

Evidence-Based Nephrology

How to Cite

Weisbord, S. D. and Palevsky, P. M. (2008) Renal Replacement Therapy in Acute Kidney Injury, in Evidence-Based Nephrology (eds D. A. Molony and J. C. Craig), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444303391.ch12

Editor Information

  1. 3

    Division of Renal Disease and Hypertension, University of Texas, USA

  2. 4

    Houston Medical School, Houston, Texas, USA

  3. 5

    School of Public Health, University of Sydney, Australia

  4. 6

    Department of Nephrology, The Children's Hospital at Westmead, Sydney, Australia

Author Information

  1. 1

    Renal Section, VA Pittsburgh Healthcare System, USA

  2. 2

    Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

Publication History

  1. Published Online: 4 MAR 2009
  2. Published Print: 5 DEC 2008

ISBN Information

Print ISBN: 9781405139755

Online ISBN: 9781444303391



  • renal replacement therapy (RRT) - cornerstone of care in patients with severe AKI;
  • continuous RRT (CRRT) and newer “hybrid” therapies - extended duration dialysis and sustained low-efficiency dialysis (SLED);
  • modality of RRT;
  • mechanistic considerations in RRT;
  • choice of dialysate buffer for CRRT;
  • RRT - mainstay of supportive care for patients with established AKI


This chapter contains sections titled:

  • Introduction

  • Prescription and delivery of RRT

  • Mechanistic considerations in RRT

  • Summary

  • Acknowledgment

  • References