Chapter 27. Toxic Nephropathies: Nonsteroidal Anti-Inflammatory Drugs

  1. Donald A. Molony MD3,4 and
  2. Jonathan C. Craig MD, PhD5,6
  1. Wai Y. Tse BSc, FRCP, PhD1 and
  2. Dwomoa Adu MD, FRCP2

Published Online: 4 MAR 2009

DOI: 10.1002/9781444303391.ch27

Evidence-Based Nephrology

Evidence-Based Nephrology

How to Cite

Tse, W. Y. and Adu, D. (2008) Toxic Nephropathies: Nonsteroidal Anti-Inflammatory Drugs, in Evidence-Based Nephrology (eds D. A. Molony and J. C. Craig), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444303391.ch27

Editor Information

  1. 3

    Division of Renal Disease and Hypertension, University of Texas, USA

  2. 4

    Houston Medical School, Houston, Texas, USA

  3. 5

    School of Public Health, University of Sydney, Australia

  4. 6

    Department of Nephrology, The Children's Hospital at Westmead, Sydney, Australia

Author Information

  1. 1

    Department of Neprology, Derriford Hospital, Plymouth, United Kingdom

  2. 2

    Department of Nephrology, Queen Elizabeth Hospital, Birmingham, United Kingdom

Publication History

  1. Published Online: 4 MAR 2009
  2. Published Print: 5 DEC 2008

ISBN Information

Print ISBN: 9781405139755

Online ISBN: 9781444303391



  • nonsteroidal anti-inflammatory drugs (NSAIDs);
  • toxic nephropathies;
  • cyclooxygenases in kidney;
  • actions of renal prostaglandins;
  • maintenance of renal blood flow and glomerular filtration rate;
  • acute tubulo-interstitial nephritis;
  • Renin release and potassium homeostasis;
  • hyperkalemia and hyporeninemic hypoaldosteronism


This chapter contains sections titled:

  • Introduction

  • Cyclooxygenases in the kidney

  • Clinical syndromes associated with nonselective and COX-2-selective NSAIDs

  • Conclusions

  • References