Chapter 37. Modalities of Extracorporeal Therapy: Hemodialysis, Hemofiltration, and Hemodiafiltration

  1. Donald A. Molony MD3,4 and
  2. Jonathan C. Craig MD, PhD5,6
  1. Kannaiyan S. Rabindranath MD1 and
  2. Norman Muirhead MD2

Published Online: 4 MAR 2009

DOI: 10.1002/9781444303391.ch37

Evidence-Based Nephrology

Evidence-Based Nephrology

How to Cite

Rabindranath, K. S. and Muirhead, N. (2008) Modalities of Extracorporeal Therapy: Hemodialysis, Hemofiltration, and Hemodiafiltration, in Evidence-Based Nephrology (eds D. A. Molony and J. C. Craig), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444303391.ch37

Editor Information

  1. 3

    Division of Renal Disease and Hypertension, University of Texas, USA

  2. 4

    Houston Medical School, Houston, Texas, USA

  3. 5

    School of Public Health, University of Sydney, Australia

  4. 6

    Department of Nephrology, The Children's Hospital at Westmead, Sydney, Australia

Author Information

  1. 1

    Renal Unit, Churchill Hospital, Oxford, United Kingdom

  2. 2

    Division of Nephrology, University of Western Ontario, London, Ontario, Canada

Publication History

  1. Published Online: 4 MAR 2009
  2. Published Print: 5 DEC 2008

ISBN Information

Print ISBN: 9781405139755

Online ISBN: 9781444303391



  • modalities of RRT;
  • extracorporeal RRT modalities;
  • hemodiafiltration (HDF);
  • current guidelines on membrane characteristics and RRT modality usage;
  • dialysis membranes - biocompatibility and flux characteristics;
  • newer RRTmodalities - HF, HDF, and AFB as predominant solute clearance modality;
  • Caring for Australians with Renal Impairment (CARI) guidelines;
  • evidence from systematic reviews of RCTs


This chapter contains sections titled:

  • Introduction

  • Principles of extracorporeal RRT modalities

  • Review of current clinical practice guidelines

  • Availability of evidence

  • Evidence from nonrandomized studies

  • Evidence from systematic reviews of RCTs

  • Extracorporeal RRT modalities

  • Critique of the evidence and guidelines

  • Conclusions

  • References