Chapter 38. Dialysis Delivery and Adequacy

  1. Donald A. Molony MD4,5 and
  2. Jonathan C. Craig MD, PhD6,7
  1. Peter Kotanko MD1,2,
  2. Nathan W. Levin MD2 and
  3. Frank Gotch MD2,3

Published Online: 4 MAR 2009

DOI: 10.1002/9781444303391.ch38

Evidence-Based Nephrology

Evidence-Based Nephrology

How to Cite

Kotanko, P., Levin, N. W. and Gotch, F. (2008) Dialysis Delivery and Adequacy, in Evidence-Based Nephrology (eds D. A. Molony and J. C. Craig), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444303391.ch38

Editor Information

  1. 4

    Division of Renal Disease and Hypertension, University of Texas, USA

  2. 5

    Houston Medical School, Houston, Texas, USA

  3. 6

    School of Public Health, University of Sydney, Australia

  4. 7

    Department of Nephrology, The Children's Hospital at Westmead, Sydney, Australia

Author Information

  1. 1

    Krankenhaus der Barmherzigen Brüder, Department of Internal Medicine, Graz, Austria

  2. 2

    Renal Research Institute, New York, USA

  3. 3

    University of California San Francisco, San Francisco, California, USA

Publication History

  1. Published Online: 4 MAR 2009
  2. Published Print: 5 DEC 2008

ISBN Information

Print ISBN: 9781405139755

Online ISBN: 9781444303391



  • dialysis delivery and adequacy;
  • dialysis dosing target;
  • residual renal urea clearance on eKt/V and estimated nPCR;
  • standard Kt/V;
  • NCDS and HEMO studies;
  • use of approximation equations;
  • dialysis adequacy and current recommendations;
  • Frequent Hemodialysis Network (FHN) trial


This chapter contains sections titled:

  • Introduction

  • Kinetic modeling

  • Dialysis delivery

  • eKt/V and spKt/V

  • Dialysis dosing target

  • Impact of residual renal urea clearance on eKt/V and estimated nPCR

  • Standard Kt/V

  • Use of approximation equations

  • The NCDS and HEMO studies

  • Dialysis adequacy: current recommendations

  • The Frequent Hemodialysis Network trial

  • References