Chapter 6. Definition, Classification, and Epidemiology of Acute Kidney Disease

  1. Donald A. Molony MD3,4 and
  2. Jonathan C. Craig MD, PhD5,6
  1. Eric A. J. Hoste MD, PhD1,2,
  2. Ramesh Venkataraman MD1 and
  3. John A. Kellum MD1

Published Online: 4 MAR 2009

DOI: 10.1002/9781444303391.ch6

Evidence-Based Nephrology

Evidence-Based Nephrology

How to Cite

Hoste, E. A. J., Venkataraman, R. and Kellum, J. A. (2008) Definition, Classification, and Epidemiology of Acute Kidney Disease, in Evidence-Based Nephrology (eds D. A. Molony and J. C. Craig), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444303391.ch6

Editor Information

  1. 3

    Division of Renal Disease and Hypertension, University of Texas, USA

  2. 4

    Houston Medical School, Houston, Texas, USA

  3. 5

    School of Public Health, University of Sydney, Australia

  4. 6

    Department of Nephrology, The Children's Hospital at Westmead, Sydney, Australia

Author Information

  1. 1

    The Clinical Research, Investigation and Systems, Modeling of Acute Illness (CRISMA) Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

  2. 2

    Intensive Care Unit, Ghent University Hospital, Ghent, Belgium

Publication History

  1. Published Online: 4 MAR 2009
  2. Published Print: 5 DEC 2008

ISBN Information

Print ISBN: 9781405139755

Online ISBN: 9781444303391



  • acute kidney injury;
  • from acute kidney failure to acute kidney injury;
  • epidemiology of AKI;
  • definition, classification and epidemiology;
  • using the RIFLE criteria for AKI;
  • limitations of RIFLE criteria;
  • biomarkers of renal tubular injury


This chapter contains sections titled:

  • Introduction

  • From acute kidney failure to acute kidney injury

  • Epidemiology of AKI

  • Outcomes in AKI

  • Limitations of the RIFLE criteria

  • Biomarkers of renal tubular injury

  • Conclusions

  • References