Chapter 2. Pathobiology of Left Ventricular Dyssynchrony and Resynchronization

  1. Kenneth A. Ellenbogen MD3,
  2. Angelo Auricchio MD, PhD Director4
  1. Robert H. Helm MD1,
  2. David D. Spragg MD1,
  3. Khalid Chakir PhD1,
  4. David A. Kass MD2

Published Online: 26 FEB 2009

DOI: 10.1002/9781444303452.ch2

Book Title

Pacing to Support the Failing Heart

Pacing to Support the Failing Heart

Additional Information

How to Cite

Helm, R. H., Spragg, D. D., Chakir, K. and Kass, D. A. (2009) Pathobiology of Left Ventricular Dyssynchrony and Resynchronization, in Pacing to Support the Failing Heart (eds K. A. Ellenbogen and A. Auricchio), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444303452.ch2

Editor Information

  1. 3

    Kontos Professor of Cardiology, Medical College of Virginia, Richmond, VA, USA

  2. 4

    Heart Failure Service, Fondazione Cardiocentro Ticino, Lugano, Switzerland

Author Information

  1. 1

    Division of Cardiology, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD, USA

  2. 2

    Abraham and Virginia Weiss Professor of Cardiology, Division of Cardiology, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD, USA

Publication History

  1. Published Online: 26 FEB 2009
  2. Published Print: 5 DEC 2008

Book Series:

  1. The AHA Clinical Series

Book Series Editors:

  1. Elliott Antman

Series Editor Information

  1. Samuel A. Levine Cardiac Unit, Brigham and Women's Hospital, USA

ISBN Information

Print ISBN: 9781405175340

Online ISBN: 9781444303452

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CHAPTER TOOLS

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Keywords:

  • heart failure and resynchronization therapy;
  • pathobiology of left ventricular dyssynchrony;
  • mechanics of dyssynchrony;
  • CRT reverses localized molecular remodeling and enhances global cell-survival signaling;
  • effect of dyssynchrony on global function and efficiency;
  • dyssynchrony, relaxation, and loading;
  • acute effects from cardiac resynchronization therapy;
  • altered gene expression;
  • electrophysiologic alterations and arrhythmia susceptibility

Summary

This chapter contains sections titled:

  • Key Points

  • Introduction: Heart failure and resynchronization therapy

  • Left ventricular dyssynchrony

  • Acute effects from cardiac resynchronization therapy

  • Chronic effects of cardiac resynchronization

  • Conclusion

  • References

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