Chapter 11. Overview of Hematopoietic Cell Transplantation Immunology

  1. Frederick R. Appelbaum MD Member Director Professor Head3,4,
  2. Stephen J. Forman MD Director Staff Physician5,6,
  3. Robert S. Negrin MD Professor of Medicine Chief7 and
  4. Karl G. Blume MD, FACP Emeritus Professor of Medicine7,8
  1. Paul J. Martin MD Member Professor of Medicine1,2

Published Online: 5 MAR 2009

DOI: 10.1002/9781444303537.ch11

Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition

Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition

How to Cite

Martin, P. J. (2009) Overview of Hematopoietic Cell Transplantation Immunology, in Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition (eds F. R. Appelbaum, S. J. Forman, R. S. Negrin and K. G. Blume), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444303537.ch11

Editor Information

  1. 3

    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

  2. 4

    Division of Medical Oncology, University of Washington School of Medicine, Seattle, Washington, USA

  3. 5

    Department of Hematology and Hematopoietic Cell Transplantation, Duarte, California, USA

  4. 6

    Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, California, USA

  5. 7

    Division of Blood and Marrow Transplantation, Stanford University, Stanford, California, USA

  6. 8

    Division of Bone Marrow Transplantation, Department of Medicine, Stanford University, School of Medicine, Stanford, California, USA

Author Information

  1. 1

    Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

  2. 2

    University of Washington, School of Medicine, Seattle, Washington, USA

Publication History

  1. Published Online: 5 MAR 2009
  2. Published Print: 27 FEB 2009

ISBN Information

Print ISBN: 9781405153485

Online ISBN: 9781444303537

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Keywords:

  • immunology;
  • hematopoietic cell transplantation immunology;
  • transplantation antigens;
  • minor histocompatibility antigens;
  • innate and adaptive immune responses;
  • selection of T cells in thymus;
  • T-cell effector functions;
  • acute GVHD;
  • immune reconstitution

Summary

This chapter contains sections titled:

  • Introduction

  • Fundamental differences between marrow transplantation and solid organ transplantation

  • Transplantation antigens

  • Movement of cells in the immune system

  • Innate and adaptive immune responses

  • Regulation of natural killer cell responses

  • Self-tolerance and alloantigen recognition by T cells

  • Activation of T-cell responses by alloantigens

  • T-cell effector functions

  • Selection of donors for allogeneic HCT

  • Outcomes influenced by genetic disparity between the donor and recipient

  • Development of tolerance

  • Immune reconstitution

  • Summary and conclusions

  • References