Chapter 14. Murine Models of Graft-versus-Host Disease and Graft-versus-Tumor Effect

  1. Frederick R. Appelbaum MD Member Director Professor Head3,4,
  2. Stephen J. Forman MD Director Staff Physician5,6,
  3. Robert S. Negrin MD Professor of Medicine Chief7 and
  4. Karl G. Blume MD, FACP Emeritus Professor of Medicine7,8
  1. Robert Korngold PhD Chief1 and
  2. Thea M. Friedman PhD Director of Research Laboratory Services2

Published Online: 5 MAR 2009

DOI: 10.1002/9781444303537.ch14

Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition

Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition

How to Cite

Korngold, R. and Friedman, T. M. (2009) Murine Models of Graft-versus-Host Disease and Graft-versus-Tumor Effect, in Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition (eds F. R. Appelbaum, S. J. Forman, R. S. Negrin and K. G. Blume), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444303537.ch14

Editor Information

  1. 3

    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

  2. 4

    Division of Medical Oncology, University of Washington School of Medicine, Seattle, Washington, USA

  3. 5

    Department of Hematology and Hematopoietic Cell Transplantation, Duarte, California, USA

  4. 6

    Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, California, USA

  5. 7

    Division of Blood and Marrow Transplantation, Stanford University, Stanford, California, USA

  6. 8

    Division of Bone Marrow Transplantation, Department of Medicine, Stanford University, School of Medicine, Stanford, California, USA

Author Information

  1. 1

    Division of Research, The Cancer Center Hackensack, University Medical Center, Hackensack, New Jersey, USA

  2. 2

    The Cancer Center at Hackensack Medical University, Hackensack, New Jersey, USA

Publication History

  1. Published Online: 5 MAR 2009
  2. Published Print: 27 FEB 2009

ISBN Information

Print ISBN: 9781405153485

Online ISBN: 9781444303537

SEARCH

Keywords:

  • Graft-versus-host disease (GVHD);
  • Murine models of Graft-versus-Host Disease and Graft-versus-Tumor Effect;
  • GVHD to H-2 class II antigens;
  • donor marrow plus donor CD4+ cells;
  • regulatory cells and GVHD;
  • effects of adding CD4+ cells;
  • GVHD in nonirradiated hosts;
  • GVHD to mHAs;
  • anti-mHA GVHD features

Summary

This chapter contains sections titled:

  • Introduction

  • Susceptibility to GVHD: the problem of host-versusgraft reactions

  • GVHD directed to MHC antigens

  • GVHD to H-2 class II antigens

  • Donor marrow plus donor CD4+ cells

  • Donor marrow plus high doses of donor CD4+ cells

  • Regulatory cells and GVHD

  • Host marrow and donor CD4+ cells

  • GVHD to H-2 class I antigens

  • Donor marrow plus donor CD8+ cells

  • Effects of adding CD4+ cells

  • GVHD in nonirradiated hosts

  • GVHD to mHAs

  • mHA target antigens

  • Features of anti-mHA GVHD

  • Role of CD8+ cells

  • Role of CD4+ cells

  • Approaches for the separation of GVHD and graft-versus-leukemia responses

  • Immunopathology

  • Summary

  • Acknowledgment

  • References