Chapter 15. Mechanisms of Tolerance

  1. Frederick R. Appelbaum MD Member Director Professor Head2,3,
  2. Stephen J. Forman MD Director Staff Physician4,5,
  3. Robert S. Negrin MD Professor of Medicine Chief6 and
  4. Karl G. Blume MD, FACP Emeritus Professor of Medicine6,7
  1. Megan Sykes MD

Published Online: 5 MAR 2009

DOI: 10.1002/9781444303537.ch15

Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition

Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition

How to Cite

Sykes, M. (2009) Mechanisms of Tolerance, in Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition (eds F. R. Appelbaum, S. J. Forman, R. S. Negrin and K. G. Blume), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444303537.ch15

Editor Information

  1. 2

    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

  2. 3

    Division of Medical Oncology, University of Washington School of Medicine, Seattle, Washington, USA

  3. 4

    Department of Hematology and Hematopoietic Cell Transplantation, Duarte, California, USA

  4. 5

    Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, California, USA

  5. 6

    Division of Blood and Marrow Transplantation, Stanford University, Stanford, California, USA

  6. 7

    Division of Bone Marrow Transplantation, Department of Medicine, Stanford University, School of Medicine, Stanford, California, USA

Author Information

  1. Transplantation Biology Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, USA

Publication History

  1. Published Online: 5 MAR 2009
  2. Published Print: 27 FEB 2009

ISBN Information

Print ISBN: 9781405153485

Online ISBN: 9781444303537



  • mechanisms of tolerance;
  • immune tolerance to a set of antigens;
  • major histocompatibility complex (MHC) barriers;
  • active suppression induction and maintenance of self- and allo tolerance;
  • approaches to inducing HVG transplantation tolerance;
  • costimulatory blockade with or without infusion of donor lymphocytes;
  • HCT in developmentally immunodeficient recipients


This chapter contains sections titled:

  • Introduction

  • Mechanisms of T-cell tolerance

  • Mechanisms of B-cell tolerance

  • Approaches to inducing HVG transplantation tolerance

  • Achieving HVG tolerance with HCT

  • Preventing GVHD by depleting or tolerizing mature donor T cells in the HCT inoculum: is GVH tolerance a desirable goal?

  • Summary and future directions

  • References