Chapter 18. The Human Graft-versus-Tumor Response – and How to Exploit It

  1. Frederick R. Appelbaum MD Member Director Professor Head2,3,
  2. Stephen J. Forman MD Director Staff Physician4,5,
  3. Robert S. Negrin MD Professor of Medicine Chief6 and
  4. Karl G. Blume MD, FACP Emeritus Professor of Medicine6,7
  1. Edus H. Warren III MD, PhD Associate Member

Published Online: 5 MAR 2009

DOI: 10.1002/9781444303537.ch18

Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition

Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition

How to Cite

Warren, E. H. (2009) The Human Graft-versus-Tumor Response – and How to Exploit It, in Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition (eds F. R. Appelbaum, S. J. Forman, R. S. Negrin and K. G. Blume), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444303537.ch18

Editor Information

  1. 2

    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

  2. 3

    Division of Medical Oncology, University of Washington School of Medicine, Seattle, Washington, USA

  3. 4

    Department of Hematology and Hematopoietic Cell Transplantation, Duarte, California, USA

  4. 5

    Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, California, USA

  5. 6

    Division of Blood and Marrow Transplantation, Stanford University, Stanford, California, USA

  6. 7

    Division of Bone Marrow Transplantation, Department of Medicine, Stanford University, School of Medicine, Stanford, California, USA

Author Information

  1. Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

Publication History

  1. Published Online: 5 MAR 2009
  2. Published Print: 27 FEB 2009

ISBN Information

Print ISBN: 9781405153485

Online ISBN: 9781444303537

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Keywords:

  • allogeneic hematopoietic cell transplantation (HCT);
  • graft-versus tumor (GVT);
  • allogeneic HCT;
  • molecular characterization of mHAs;
  • classification of mHA-encoding genes;
  • contributions of mHA-specific T-cell response to GVT;
  • expression of mHAs in normal tissues and leukemia;
  • B-cell contributions to GVT;
  • human genomic diversity and number of mHAs

Summary

This chapter contains sections titled:

  • Introduction

  • Defining characteristics of the GVT effect in human allogeneic HCT

  • Identifying the genetic determinants, effector cells, and target molecules of the GVT effect

  • Strategies for exploiting the GVT response

  • Conclusion

  • References