Chapter 20. The Experimental Basis for Hematopoietic Cell Transplantation for Autoimmune Diseases

  1. Frederick R. Appelbaum MD Member Director Professor Head2,3,
  2. Stephen J. Forman MD Director Staff Physician4,5,
  3. Robert S. Negrin MD Professor of Medicine Chief6 and
  4. Karl G. Blume MD, FACP Emeritus Professor of Medicine6,7
  1. Judith A. Shizuru PhD, MD Associate Professor of Medicine

Published Online: 5 MAR 2009

DOI: 10.1002/9781444303537.ch20

Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition

Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition

How to Cite

Shizuru, J. A. (2009) The Experimental Basis for Hematopoietic Cell Transplantation for Autoimmune Diseases, in Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition (eds F. R. Appelbaum, S. J. Forman, R. S. Negrin and K. G. Blume), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444303537.ch20

Editor Information

  1. 2

    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

  2. 3

    Division of Medical Oncology, University of Washington School of Medicine, Seattle, Washington, USA

  3. 4

    Department of Hematology and Hematopoietic Cell Transplantation, Duarte, California, USA

  4. 5

    Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, California, USA

  5. 6

    Division of Blood and Marrow Transplantation, Stanford University, Stanford, California, USA

  6. 7

    Division of Bone Marrow Transplantation, Department of Medicine, Stanford University, School of Medicine, Stanford, California, USA

Author Information

  1. Division of Blood and Marrow Transplantation, Department of Medicine, Stanford University, School of Medicine, Stanford, California, USA

Publication History

  1. Published Online: 5 MAR 2009
  2. Published Print: 27 FEB 2009

ISBN Information

Print ISBN: 9781405153485

Online ISBN: 9781444303537

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Keywords:

  • experimental basis for hematopoietic cell transplantation for autoimmune diseases;
  • autoimmune diseases (ADs) - heterogeneous group of disorders;
  • immunologic ignorance;
  • autoimmune pathology;
  • triggers autoreactivity;
  • spontaneously arising ADs;
  • HCT and treatment of ADs;
  • treatment of spontaneous ADs with allogeneic HCT;
  • replacement of susceptibility genes of host

Summary

This chapter contains sections titled:

  • Introduction

  • The immune response

  • Autoimmune pathology

  • Animal models of AD

  • HCT and the treatment of ADs

  • Autologous HCT

  • Allogeneic HCT

  • Conclusion

  • References