Chapter 21. Pharmacologic Basis for High-dose Chemotherapy

  1. Frederick R. Appelbaum MD Member Director Professor Head3,4,
  2. Stephen J. Forman MD Director Staff Physician5,6,
  3. Robert S. Negrin MD Professor of Medicine Chief7 and
  4. Karl G. Blume MD, FACP Emeritus Professor of Medicine7,8
  1. James H. Doroshow MD, FACP Chairman Associate Director for Clinical Investigation6 and
  2. Timothy W. Synold Pharm.D. Associate Professor1,2

Published Online: 5 MAR 2009

DOI: 10.1002/9781444303537.ch21

Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition

Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition

How to Cite

Doroshow, J. H. and Synold, T. W. (2009) Pharmacologic Basis for High-dose Chemotherapy, in Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition (eds F. R. Appelbaum, S. J. Forman, R. S. Negrin and K. G. Blume), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444303537.ch21

Editor Information

  1. 3

    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

  2. 4

    Division of Medical Oncology, University of Washington School of Medicine, Seattle, Washington, USA

  3. 5

    Department of Hematology and Hematopoietic Cell Transplantation, Duarte, California, USA

  4. 6

    Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, California, USA

  5. 7

    Division of Blood and Marrow Transplantation, Stanford University, Stanford, California, USA

  6. 8

    Division of Bone Marrow Transplantation, Department of Medicine, Stanford University, School of Medicine, Stanford, California, USA

Author Information

  1. 1

    Department of Clinical and Molecular Pharmacology, Duarte, California, USA

  2. 2

    Analytical Pharmacology Core Facility, City of Hope Comprehensive Cancer Center, Duarte, California, USA

  3. 6

    Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, California, USA

Publication History

  1. Published Online: 5 MAR 2009
  2. Published Print: 27 FEB 2009

ISBN Information

Print ISBN: 9781405153485

Online ISBN: 9781444303537

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Keywords:

  • pharmacologic rationale for high-dose chemotherapy;
  • pharmacologic definition of high-dose chemotherapy;
  • tumor cell resistance to high-dose chemotherapy;
  • cytochrome P-450 2B subfamily;
  • therapeutic drug selection and drug development in high-dose chemotherapy setting;
  • cyclophosphamide;
  • metabolism, pharmacokinetics, and pharmacodynamics;
  • Platinating agents

Summary

This chapter contains sections titled:

  • Introduction

  • Pharmacologic rationale for high-dose chemotherapy

  • Clinical pharmacology of drugs utilized for high-dose chemotherapy and HCT: pharmacokinetic, pharmacodynamic, and mechanistic considerations

  • Conclusion

  • References