Chapter 23. Radiotherapeutic Principles of Hematopoietic Cell Transplantation

  1. Frederick R. Appelbaum MD Member Director Professor Head2,3,
  2. Stephen J. Forman MD Director Staff Physician4,5,
  3. Robert S. Negrin MD Professor of Medicine Chief6 and
  4. Karl G. Blume MD, FACP Emeritus Professor of Medicine6,7
  1. Jeffrey Y. C. Wong MD Professor Chair and
  2. Timothy Schultheiss PhD Department Director Professor

Published Online: 5 MAR 2009

DOI: 10.1002/9781444303537.ch23

Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition

Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition

How to Cite

Wong, J. Y. C. and Schultheiss, T. (2009) Radiotherapeutic Principles of Hematopoietic Cell Transplantation, in Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition (eds F. R. Appelbaum, S. J. Forman, R. S. Negrin and K. G. Blume), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444303537.ch23

Editor Information

  1. 2

    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

  2. 3

    Division of Medical Oncology, University of Washington School of Medicine, Seattle, Washington, USA

  3. 4

    Department of Hematology and Hematopoietic Cell Transplantation, Duarte, California, USA

  4. 5

    Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, California, USA

  5. 6

    Division of Blood and Marrow Transplantation, Stanford University, Stanford, California, USA

  6. 7

    Division of Bone Marrow Transplantation, Department of Medicine, Stanford University, School of Medicine, Stanford, California, USA

Author Information

  1. Division of Radiation, Oncology, City of Hope Cancer Center, Duarte, California, USA

Publication History

  1. Published Online: 5 MAR 2009
  2. Published Print: 27 FEB 2009

ISBN Information

Print ISBN: 9781405153485

Online ISBN: 9781444303537

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Keywords:

  • radiotherapeutic principles of hematopoietic cell transplantation;
  • high-dose TBI-containing regimens;
  • acute toxicities associated with high-dose TBI-containing regimens;
  • radiation physics and physical considerations;
  • high-dose TBI-containing regimens - normal tissue effects;
  • Involved field radiation therapy (IFRT)

Summary

This chapter contains sections titled:

  • Introduction

  • Radiobiologic principles

  • Radiation physics and physical considerations

  • High-dose TBI-containing regimens: clinical results

  • High-dose TBI-containing regimens: normal tissue effects

  • High-dose TBI-containing versus non-TBI-containing regimens

  • TBI and reduced-intensity regimens

  • Total lymphoid irradiation

  • Involved field radiotherapy

  • Targeted TBI and future directions

  • Summary

  • References