Chapter 26. The Detection and Significance of Minimal Residual Disease

  1. Frederick R. Appelbaum MD Member Director Professor Head2,3,
  2. Stephen J. Forman MD Director Staff Physician4,5,
  3. Robert S. Negrin MD Professor of Medicine Chief6 and
  4. Karl G. Blume MD, FACP Emeritus Professor of Medicine6,7
  1. Jerald P. Radich MD Member2 and
  2. Marilyn L. Slovak PhD, FACMG Director1

Published Online: 5 MAR 2009

DOI: 10.1002/9781444303537.ch26

Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition

Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition

How to Cite

Radich, J. P. and Slovak, M. L. (2009) The Detection and Significance of Minimal Residual Disease, in Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition (eds F. R. Appelbaum, S. J. Forman, R. S. Negrin and K. G. Blume), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444303537.ch26

Editor Information

  1. 2

    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

  2. 3

    Division of Medical Oncology, University of Washington School of Medicine, Seattle, Washington, USA

  3. 4

    Department of Hematology and Hematopoietic Cell Transplantation, Duarte, California, USA

  4. 5

    Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, California, USA

  5. 6

    Division of Blood and Marrow Transplantation, Stanford University, Stanford, California, USA

  6. 7

    Division of Bone Marrow Transplantation, Department of Medicine, Stanford University, School of Medicine, Stanford, California, USA

Author Information

  1. 1

    Department of Cytogenics, City of Hope, Duarte, California, USA

  2. 2

    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

Publication History

  1. Published Online: 5 MAR 2009
  2. Published Print: 27 FEB 2009

ISBN Information

Print ISBN: 9781405153485

Online ISBN: 9781444303537

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Keywords:

  • detection and significance of minimal residual disease;
  • common assays for detection of minimal residual disease (MRD);
  • flow cytometry assays;
  • methods of MRD detection;
  • polymerase chain reaction;
  • need for uniform or standardized MRD testing – critical issue

Summary

This chapter contains sections titled:

  • Introduction

  • Methods of MRD detection

  • The clinical significance of MRD

  • Problems and promise

  • Conclusion

  • References