Chapter 39. Cord Blood Hematopoietic Cell Transplantation

  1. Frederick R. Appelbaum MD Member Director Professor Head4,5,
  2. Stephen J. Forman MD Director Staff Physician6,7,
  3. Robert S. Negrin MD Professor of Medicine Chief8 and
  4. Karl G. Blume MD, FACP Emeritus Professor of Medicine8,9
  1. Hal E. Broxmeyer PhD Chairman Professor of Medicine Scientific Director1,2 and
  2. Franklin O. Smith MD Director3

Published Online: 5 MAR 2009

DOI: 10.1002/9781444303537.ch39

Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition

Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition

How to Cite

Broxmeyer, H. E. and Smith, F. O. (2009) Cord Blood Hematopoietic Cell Transplantation, in Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition (eds F. R. Appelbaum, S. J. Forman, R. S. Negrin and K. G. Blume), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444303537.ch39

Editor Information

  1. 4

    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

  2. 5

    Division of Medical Oncology, University of Washington School of Medicine, Seattle, Washington, USA

  3. 6

    Department of Hematology and Hematopoietic Cell Transplantation, Duarte, California, USA

  4. 7

    Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, California, USA

  5. 8

    Division of Blood and Marrow Transplantation, Stanford University, Stanford, California, USA

  6. 9

    Division of Bone Marrow Transplantation, Department of Medicine, Stanford University, School of Medicine, Stanford, California, USA

Author Information

  1. 1

    Mary Margaret Walther Professor of Microbiology and Immunology, Indianapolis, Indiana, USA

  2. 2

    The Walther Oncology Center Indiana, University School of Medicine Cancer Research Institute, Indianapolis, Indiana, USA

  3. 3

    Division of Hematology/Oncology Professor of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA

Publication History

  1. Published Online: 5 MAR 2009
  2. Published Print: 27 FEB 2009

ISBN Information

Print ISBN: 9781405153485

Online ISBN: 9781444303537



  • cord blood hematopoietic cell transplantation;
  • searching for UCB donor;
  • History of UCB transplantation;
  • umbilical cord blood (UCB) hematopoietic cells - alternative source of hematopoietic stem cells (HSCs);
  • UCB banking;
  • related donor UCB transplantation;
  • unrelated donor UCB transplantation;
  • immune reconstitution after UCB transplantation;
  • gene therapy of UCB stem cells


This chapter contains sections titled:

  • Introduction

  • History of UCB transplantation

  • Collection of UCB

  • UCB banking

  • Searching for a UCB donor

  • Clinical results

  • Characteristics of primitive hematopoietic stem and progenitor cells in UCB

  • Endothelial progenitor cells and mesenchymal stem/stromal cells in cord blood

  • Ex vivo expansion of UCB stem cells

  • Gene therapy of UCB stem cells

  • Homing of UCB stem cells

  • Immune cells

  • Additional information and conclusion

  • References