Chapter 4. Generation of Definitive Engraftable Hematopoietic Stem Cells from Human Embryonic Stem Cells

  1. Frederick R. Appelbaum MD Member Director Professor Head6,7,
  2. Stephen J. Forman MD Director Staff Physician8,9,
  3. Robert S. Negrin MD Professor of Medicine Chief10 and
  4. Karl G. Blume MD, FACP Emeritus Professor of Medicine10,11
  1. Laurence Dahéron PhD1 and
  2. David T. Scadden MD Director Chief2,3,4,5

Published Online: 5 MAR 2009

DOI: 10.1002/9781444303537.ch4

Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition

Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition

How to Cite

Dahéron, L. and Scadden, D. T. (2009) Generation of Definitive Engraftable Hematopoietic Stem Cells from Human Embryonic Stem Cells, in Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition (eds F. R. Appelbaum, S. J. Forman, R. S. Negrin and K. G. Blume), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444303537.ch4

Editor Information

  1. 6

    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

  2. 7

    Division of Medical Oncology, University of Washington School of Medicine, Seattle, Washington, USA

  3. 8

    Department of Hematology and Hematopoietic Cell Transplantation, Duarte, California, USA

  4. 9

    Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, California, USA

  5. 10

    Division of Blood and Marrow Transplantation, Stanford University, Stanford, California, USA

  6. 11

    Division of Bone Marrow Transplantation, Department of Medicine, Stanford University, School of Medicine, Stanford, California, USA

Author Information

  1. 1

    Massachusetts General Hospital, Center for Regenerative, Medicine, Boston, Massachusetts, USA

  2. 2

    Gerald and Darlene Jordan Professor of Medicine, Department of Stem Cell and Regenerative Biology, Boston, Massachusetts, USA

  3. 3

    Harvard Stem Cell Institute, Harvard University, Boston, Massachusetts, USA

  4. 4

    MGH Center for Regenerative Medicine, Boston, Massachusetts, USA

  5. 5

    Hematologic Malignancies, MGH Cancer Center, Massachusetts General Hospital, Boston, Massachusetts, USA

Publication History

  1. Published Online: 5 MAR 2009
  2. Published Print: 27 FEB 2009

ISBN Information

Print ISBN: 9781405153485

Online ISBN: 9781444303537

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Keywords:

  • hematopoiesis and stem cell biology;
  • human embryonic stem cells (hESCs);
  • engraftable hematopoietic stem cells from human embryonic stem cells;
  • derivation of blood-specific lineages from hESCs;
  • dendritic cells (DCs) - potent antigen-presenting cells;
  • isolation and/or expansion of hESC-derived HSCs;
  • transplantation of HSCs derived from hESCs;
  • generating immunologically compatible HSCs

Summary

This chapter contains sections titled:

  • Introduction

  • Generation of HSCs from ESCs

  • Isolation and/or expansion of hESC-derived HSCs

  • Are ESC-derived hematopoietic progenitors capable of engraftment and hematopoietic repopulation?

  • Can we generate immunologically compatible HSCs?

  • Conclusion

  • References