Chapter 41. Mobilization of Autologous Peripheral Blood Hematopoietic Cells for Cellular Therapy

  1. Frederick R. Appelbaum MD Member Director Professor Head4,5,
  2. Stephen J. Forman MD Director Staff Physician6,7,
  3. Robert S. Negrin MD Professor of Medicine Chief8 and
  4. Karl G. Blume MD, FACP Emeritus Professor of Medicine8,9
  1. Thomas C. Shea MD1 and
  2. John F. DiPersio MD, PhD Chief Deputy Director2,3

Published Online: 5 MAR 2009

DOI: 10.1002/9781444303537.ch41

Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition

Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition

How to Cite

Shea, T. C. and DiPersio, J. F. (2009) Mobilization of Autologous Peripheral Blood Hematopoietic Cells for Cellular Therapy, in Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition (eds F. R. Appelbaum, S. J. Forman, R. S. Negrin and K. G. Blume), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444303537.ch41

Editor Information

  1. 4

    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

  2. 5

    Division of Medical Oncology, University of Washington School of Medicine, Seattle, Washington, USA

  3. 6

    Department of Hematology and Hematopoietic Cell Transplantation, Duarte, California, USA

  4. 7

    Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, California, USA

  5. 8

    Division of Blood and Marrow Transplantation, Stanford University, Stanford, California, USA

  6. 9

    Division of Bone Marrow Transplantation, Department of Medicine, Stanford University, School of Medicine, Stanford, California, USA

Author Information

  1. 1

    University of North Carolina at Chapel Hill, School of Medicine, Division of Hematology/Oncology, Chapel Hill, North Carolina, USA

  2. 2

    Division of Oncology, St Louis, Missouri, USA

  3. 3

    Siteman Cancer Research, Washington University School of Medicine, St Louis, Missouri, USA

Publication History

  1. Published Online: 5 MAR 2009
  2. Published Print: 27 FEB 2009

ISBN Information

Print ISBN: 9781405153485

Online ISBN: 9781444303537

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Keywords:

  • mobilization of autologous peripheral blood hematopoietic cells for cellular therapy;
  • role of proteases;
  • effect of other cell adhesion molecules on HSC mobilization;
  • clinical applications;
  • identifying optimal cell yield;
  • cytokine-induced mobilization;
  • tumor contamination;
  • guidelines for “hard to mobilize” patient;
  • high-dose therapy and autologous PBHC-supported transplantation and hematologic malignancies

Summary

This chapter contains sections titled:

  • Introduction

  • Identification and enumeration

  • Mechanisms of progenitor cell mobilization

  • Evidence for the pivotal role of SDF-1/CXCR4 in HSC mobilization and trafficking

  • Clinical applications

  • Collection techniques

  • Identifying the optimal cell yield

  • Cytokine-induced mobilization

  • Combination cytokine- and cytokine-plus chemotherapy-induced mobilization

  • Factors affecting yield of PBHC mobilization

  • Tumor contamination

  • Future directions

  • Summary

  • References