Chapter 5. Biology of Hematopoietic Stem and Progenitor Cells

  1. Frederick R. Appelbaum MD Member Director Professor Head3,4,
  2. Stephen J. Forman MD Director Staff Physician5,6,
  3. Robert S. Negrin MD Professor of Medicine Chief7 and
  4. Karl G. Blume MD, FACP Emeritus Professor of Medicine7,8
  1. Susan Prohaska PhD1 and
  2. Irving Weissman MD Director1,2

Published Online: 5 MAR 2009

DOI: 10.1002/9781444303537.ch5

Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition

Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition

How to Cite

Prohaska, S. and Weissman, I. (2009) Biology of Hematopoietic Stem and Progenitor Cells, in Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition (eds F. R. Appelbaum, S. J. Forman, R. S. Negrin and K. G. Blume), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444303537.ch5

Editor Information

  1. 3

    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

  2. 4

    Division of Medical Oncology, University of Washington School of Medicine, Seattle, Washington, USA

  3. 5

    Department of Hematology and Hematopoietic Cell Transplantation, Duarte, California, USA

  4. 6

    Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, California, USA

  5. 7

    Division of Blood and Marrow Transplantation, Stanford University, Stanford, California, USA

  6. 8

    Division of Bone Marrow Transplantation, Department of Medicine, Stanford University, School of Medicine, Stanford, California, USA

Author Information

  1. 1

    Stanford Institute for Stem Cell Biology and Regenerative Medicine Director, Stanford, California, USA

  2. 2

    Ludwig Center at Stanford, University of Stanford, California, USA

Publication History

  1. Published Online: 5 MAR 2009
  2. Published Print: 27 FEB 2009

ISBN Information

Print ISBN: 9781405153485

Online ISBN: 9781444303537

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Keywords:

  • biology of hematopoietic stem and progenitor cells;
  • history of HSC isolation;
  • genetic pathways for self-renewal of HSCs;
  • migration of HSCs;
  • ontogeny and aging of HSCs;
  • CLP cells and lymphoid development;
  • lineage-committed hematopoietic progenitor cells;
  • alternative developmental pathways;
  • gene expression profile of stem and progenitor cells;
  • LSC marker identification crucial to effective treatment strategies

Summary

This chapter contains sections titled:

  • Introduction

  • History of HSC isolation

  • Properties of mouse HSCs and other MPPs

  • Lineage-committed hematopoietic progenitor cells

  • Gene expression profiles of HSCs

  • Gene expression profile of stem and progenitor cells

  • Transplantation of HSCs in mouse and humans

  • Co-transplantation of HSCs and hematopoietic progenitors to protect against opportunistic infections

  • Origin of leukemia: LSCs

  • Conclusion

  • References