Chapter 50. Hematopoietic Cell Transplantation for Paroxysmal Nocturnal Hemoglobinuria

  1. Frederick R. Appelbaum MD Member Director Professor Head4,5,
  2. Stephen J. Forman MD Director Staff Physician6,7,
  3. Robert S. Negrin MD Professor of Medicine Chief8 and
  4. Karl G. Blume MD, FACP Emeritus Professor of Medicine8,9
  1. Robert P. Witherspoon MD Member Professor of Medicine Medical Director1,2,3

Published Online: 5 MAR 2009

DOI: 10.1002/9781444303537.ch50

Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition

Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition

How to Cite

Witherspoon, R. P. (2009) Hematopoietic Cell Transplantation for Paroxysmal Nocturnal Hemoglobinuria, in Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition (eds F. R. Appelbaum, S. J. Forman, R. S. Negrin and K. G. Blume), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444303537.ch50

Editor Information

  1. 4

    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

  2. 5

    Division of Medical Oncology, University of Washington School of Medicine, Seattle, Washington, USA

  3. 6

    Department of Hematology and Hematopoietic Cell Transplantation, Duarte, California, USA

  4. 7

    Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, California, USA

  5. 8

    Division of Blood and Marrow Transplantation, Stanford University, Stanford, California, USA

  6. 9

    Division of Bone Marrow Transplantation, Department of Medicine, Stanford University, School of Medicine, Stanford, California, USA

Author Information

  1. 1

    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

  2. 2

    University of Washington, Seattle, Washington, USA

  3. 3

    Transplant Clinic, Seattle Cancer Care Alliance, Seattle, Washington, USA

Publication History

  1. Published Online: 5 MAR 2009
  2. Published Print: 27 FEB 2009

ISBN Information

Print ISBN: 9781405153485

Online ISBN: 9781444303537

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Keywords:

  • hematopoietic cell transplantation for paroxysmal nocturnal hemoglobinuria;
  • paroxysmal nocturnal hemoglobinuria (PNH);
  • nontransplant treatment of PNH;
  • autologous transplantation for PNH;
  • transplants following reduced-intensity conditioning

Summary

This chapter contains sections titled:

  • Introduction

  • Epidemiology and etiology

  • Molecular and clinical biology

  • Clinical description of PNH

  • Nontransplant treatment of PNH

  • Transplantation for PNH

  • Transplants following reduced-intensity conditioning

  • Autologous transplantation for PNH

  • Conclusion

  • References