Chapter 65. Hematopoietic Cell Transplantation for Renal Cell and other Solid Tumors

  1. Frederick R. Appelbaum MD Member Director Professor Head3,4,
  2. Stephen J. Forman MD Director Staff Physician5,6,
  3. Robert S. Negrin MD Professor of Medicine Chief7 and
  4. Karl G. Blume MD, FACP Emeritus Professor of Medicine7,8
  1. Richard W. Childs MD Senior Investigator1 and
  2. Ramaprasad Srinivasan MD, PhD2

Published Online: 5 MAR 2009

DOI: 10.1002/9781444303537.ch65

Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition

Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition

How to Cite

Childs, R. W. and Srinivasan, R. (2009) Hematopoietic Cell Transplantation for Renal Cell and other Solid Tumors, in Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition (eds F. R. Appelbaum, S. J. Forman, R. S. Negrin and K. G. Blume), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444303537.ch65

Editor Information

  1. 3

    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

  2. 4

    Division of Medical Oncology, University of Washington School of Medicine, Seattle, Washington, USA

  3. 5

    Department of Hematology and Hematopoietic Cell Transplantation, Duarte, California, USA

  4. 6

    Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, California, USA

  5. 7

    Division of Blood and Marrow Transplantation, Stanford University, Stanford, California, USA

  6. 8

    Division of Bone Marrow Transplantation, Department of Medicine, Stanford University, School of Medicine, Stanford, California, USA

Author Information

  1. 1

    National Heart, Lung and Blood Institute, National Institutes of Health, Bethseda, Maryland, USA

  2. 2

    Urologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA

Publication History

  1. Published Online: 5 MAR 2009
  2. Published Print: 27 FEB 2009

ISBN Information

Print ISBN: 9781405153485

Online ISBN: 9781444303537

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Keywords:

  • hematopoietic cell transplantation for renal cell and other solid tumors;
  • solid tumors as GVT target;
  • immune system and solid tumors;
  • Allogeneic transplantation as immunotherapy: the GVT effect;
  • Use of reduced-intensity conditioning in allogeneic transplantation for solid tumors;
  • RIC HCT in other solid tumors;
  • Mechanisms underlying GVT effects in solid tumors

Summary

This chapter contains sections titled:

  • Introduction

  • Allogeneic transplantation as immunotherapy: the GVT effect

  • The immune system and solid tumors

  • Solid tumors as a GVT target

  • Use of reduced-intensity conditioning in allogeneic transplantation for solid tumors

  • Clinical results of reduced-intensity allogeneic HCT transplantation in solid tumors

  • Emerging role of RIC HCT for RCC

  • Toxicities and limitations of RIC HCT in metastatic RCC

  • RIC HCT in melanoma

  • RIC HCT in other solid tumors

  • Mechanisms underlying GVT effects in solid tumors

  • Future directions

  • References