Chapter 66. Hematopoietic Cell Transplantation for Neuroblastoma

  1. Frederick R. Appelbaum MD Member Director Professor Head3,4,
  2. Stephen J. Forman MD Director Staff Physician5,6,
  3. Robert S. Negrin MD Professor of Medicine Chief7 and
  4. Karl G. Blume MD, FACP Emeritus Professor of Medicine7,8
  1. Jason Law and
  2. Katherine K. Matthay MD Professor of Pediatrics Chief1,2

Published Online: 5 MAR 2009

DOI: 10.1002/9781444303537.ch66

Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition

Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition

How to Cite

Law, J. and Matthay, K. K. (2009) Hematopoietic Cell Transplantation for Neuroblastoma, in Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition (eds F. R. Appelbaum, S. J. Forman, R. S. Negrin and K. G. Blume), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444303537.ch66

Editor Information

  1. 3

    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

  2. 4

    Division of Medical Oncology, University of Washington School of Medicine, Seattle, Washington, USA

  3. 5

    Department of Hematology and Hematopoietic Cell Transplantation, Duarte, California, USA

  4. 6

    Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, California, USA

  5. 7

    Division of Blood and Marrow Transplantation, Stanford University, Stanford, California, USA

  6. 8

    Division of Bone Marrow Transplantation, Department of Medicine, Stanford University, School of Medicine, Stanford, California, USA

Author Information

  1. 1

    University of California School of Medicine, San Francisco, CA, USA

  2. 2

    Pediatric Hematology-Oncology Department UCSF, San Francisco, CA, USA

Publication History

  1. Published Online: 5 MAR 2009
  2. Published Print: 27 FEB 2009

ISBN Information

Print ISBN: 9781405153485

Online ISBN: 9781444303537



  • hematopoietic cell transplantation for neuroblastoma;
  • risk classification and treatment approach;
  • Current Children's Oncology Group neuroblastoma risk classification;
  • treatment of high-risk neuroblastoma;
  • induction therapy;
  • high-dose conditioning regimens;
  • tandem transplants;
  • acute and late complications of HCT in neuroblastoma


This chapter contains sections titled:

  • Introduction

  • Clinical presentation and staging

  • Tumor molecular biology

  • Risk classification and treatment approach

  • Treatment of high-risk neuroblastoma

  • Induction therapy

  • Local control

  • Evolution of high-dose conditioning

  • Nonrandomized comparisons of HCT to chemotherapy

  • Randomized comparison of autologous BMT to standard-dose chemotherapy

  • High-dose conditioning regimens

  • Tandem transplants

  • Targeted radionuclides as part of high-dose therapy

  • Allogeneic transplantation

  • Hematopoietic cell source and purging

  • Treatment of minimal residual disease

  • Acute and late complications of HCT in neuroblastoma

  • Conclusion

  • References