Chapter 69. Hematopoietic Cell Transplantation for Autoimmune Diseases

  1. Frederick R. Appelbaum MD Member Director Professor Head3,4,
  2. Stephen J. Forman MD Director Staff Physician5,6,
  3. Robert S. Negrin MD Professor of Medicine Chief7 and
  4. Karl G. Blume MD, FACP Emeritus Professor of Medicine7,8
  1. Richard A. Nash MD Member Associate Professor1,2

Published Online: 5 MAR 2009

DOI: 10.1002/9781444303537.ch69

Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition

Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition

How to Cite

Nash, R. A. (2009) Hematopoietic Cell Transplantation for Autoimmune Diseases, in Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition (eds F. R. Appelbaum, S. J. Forman, R. S. Negrin and K. G. Blume), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444303537.ch69

Editor Information

  1. 3

    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

  2. 4

    Division of Medical Oncology, University of Washington School of Medicine, Seattle, Washington, USA

  3. 5

    Department of Hematology and Hematopoietic Cell Transplantation, Duarte, California, USA

  4. 6

    Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, California, USA

  5. 7

    Division of Blood and Marrow Transplantation, Stanford University, Stanford, California, USA

  6. 8

    Division of Bone Marrow Transplantation, Department of Medicine, Stanford University, School of Medicine, Stanford, California, USA

Author Information

  1. 1

    Program in Transplantation Biology Clinical Research Division Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

  2. 2

    University of Washington, Seattle, Washington, USA

Publication History

  1. Published Online: 5 MAR 2009
  2. Published Print: 27 FEB 2009

ISBN Information

Print ISBN: 9781405153485

Online ISBN: 9781444303537

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Keywords:

  • hematopoietic cell transplantation for autoimmune diseases;
  • preclinical models of autoimmunity and HCT;
  • single-gene defects associated with autoimmunity;
  • HDIT and autologous HCT for autoimmune diseases;
  • HDIT regimens;
  • immune reconstitution after HDIT regimen;
  • specific autoimmune diseases and HCT;
  • multiple sclerosis;
  • systemic sclerosis

Summary

This chapter contains sections titled:

  • Introduction

  • Proposed mechanisms for autoimmunity and autoimmune diseases

  • Preclinical models of autoimmunity and HCT

  • Outcomes in patients with autoimmune diseases transplanted for another primary disease

  • HDIT and autologous HCT for autoimmune diseases: clinical experience

  • Allogeneic HCT for autoimmune diseases: clinical experience

  • Autoimmunity after HCT

  • Conclusion

  • References