Chapter 75. Hematopoietic Cell Transplantation for Immunodeficiency Diseases

  1. Frederick R. Appelbaum MD Member Director Professor Head5,6,
  2. Stephen J. Forman MD Director Staff Physician7,8,
  3. Robert S. Negrin MD Professor of Medicine Chief9 and
  4. Karl G. Blume MD, FACP Emeritus Professor of Medicine9,10
  1. Trudy N. Small MD Associate Attending1,
  2. Wilhelm Friedrich MD Professor of Pediatrics2 and
  3. Richard J. O'Reilly MD Chairman Chief3,4

Published Online: 5 MAR 2009

DOI: 10.1002/9781444303537.ch75

Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition

Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition

How to Cite

Small, T. N., Friedrich, W. and O'Reilly, R. J. (2009) Hematopoietic Cell Transplantation for Immunodeficiency Diseases, in Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition (eds F. R. Appelbaum, S. J. Forman, R. S. Negrin and K. G. Blume), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444303537.ch75

Editor Information

  1. 5

    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

  2. 6

    Division of Medical Oncology, University of Washington School of Medicine, Seattle, Washington, USA

  3. 7

    Department of Hematology and Hematopoietic Cell Transplantation, Duarte, California, USA

  4. 8

    Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, California, USA

  5. 9

    Division of Blood and Marrow Transplantation, Stanford University, Stanford, California, USA

  6. 10

    Division of Bone Marrow Transplantation, Department of Medicine, Stanford University, School of Medicine, Stanford, California, USA

Author Information

  1. 1

    Department of Pediatrics Bone Marrow Transplantation Service, Memorial Sloan-Kettering Cancer Center, New York, New York, USA

  2. 2

    Department of Pediatrics, University Children's Hospital Ulm, University of Ulm, Ulm, Germany

  3. 3

    Department of Pediatrics, New York, USA

  4. 4

    Marrow Transplantation Service, Memorial Sloan-Kettering Center, New York, New York, USA

Publication History

  1. Published Online: 5 MAR 2009
  2. Published Print: 27 FEB 2009

ISBN Information

Print ISBN: 9781405153485

Online ISBN: 9781444303537

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Keywords:

  • hematopoietic cell transplantation for immunodeficiency diseases;
  • unmodified human leukocyte antigen-matched related HCT;
  • alternative donor transplants for SCID;
  • reduced-intensity conditioning and HCT for SCID;
  • gene therapy for SCID and other lethal disorders of immunity;
  • lethal immunodeficiencies

Summary

This chapter contains sections titled:

  • Introduction

  • Severe combined immunodeficiency syndrome

  • HCT for SCID

  • Wiskott-Aldrich syndrome

  • Gene therapy for SCID and other lethal disorders of immunity

  • X-linked γc-deficient SCID

  • Other lethal immunodeficiencies

  • Conclusion

  • References