Chapter 8. Expansion of Hematopoietic Stem Cells

  1. Frederick R. Appelbaum MD Member Director Professor Head5,6,
  2. Stephen J. Forman MD Director Staff Physician7,8,
  3. Robert S. Negrin MD Professor of Medicine Chief9 and
  4. Karl G. Blume MD, FACP Emeritus Professor of Medicine9,10
  1. Colleen Delaney MD, MSc Assistant Member Assistant Professor2,5 and
  2. Irwin Bernstein MD Member Professor of Medicine3,4

Published Online: 5 MAR 2009

DOI: 10.1002/9781444303537.ch8

Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition

Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition

How to Cite

Delaney, C. and Bernstein, I. (2009) Expansion of Hematopoietic Stem Cells, in Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition (eds F. R. Appelbaum, S. J. Forman, R. S. Negrin and K. G. Blume), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444303537.ch8

Editor Information

  1. 5

    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

  2. 6

    Division of Medical Oncology, University of Washington School of Medicine, Seattle, Washington, USA

  3. 7

    Department of Hematology and Hematopoietic Cell Transplantation, Duarte, California, USA

  4. 8

    Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, California, USA

  5. 9

    Division of Blood and Marrow Transplantation, Stanford University, Stanford, California, USA

  6. 10

    Division of Bone Marrow Transplantation, Department of Medicine, Stanford University, School of Medicine, Stanford, California, USA

Author Information

  1. 2

    Department of Pediatrics, University of Washington, School of Medicine, Seattle, Washington, USA

  2. 3

    Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

  3. 4

    University of Washington School of Medicine, Seattle, Washington, USA

  4. 5

    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

Publication History

  1. Published Online: 5 MAR 2009
  2. Published Print: 27 FEB 2009

ISBN Information

Print ISBN: 9781405153485

Online ISBN: 9781444303537

SEARCH

Keywords:

  • expansion of hematopoietic stem cells;
  • growth factor and stroma-induced expansion;
  • xenogeneic animal models - transplantation of human cells;
  • novel approaches for ex vivo HSC expansion;
  • clinical trials using bone marrow and mobilized peripheral blood;
  • clinical trials using UCB cells;
  • continued development of methods using novel stem cell regulators

Summary

This chapter contains sections titled:

  • Introduction

  • Preclinical studies: growth factor and stroma-induced expansion

  • Clinical trials of ex vivo expanded HSCs

  • Conclusion

  • References