Chapter 80. Mechanisms and Treatment of Graft Failure

  1. Frederick R. Appelbaum MD Member Director Professor Head4,5,
  2. Stephen J. Forman MD Director Staff Physician6,7,
  3. Robert S. Negrin MD Professor of Medicine Chief8 and
  4. Karl G. Blume MD, FACP Emeritus Professor of Medicine8,9
  1. Robert Lowsky MD Assistant Professor of Medicine1 and
  2. Hans Messner MD, PhD Director Senior Scientist2

Published Online: 5 MAR 2009

DOI: 10.1002/9781444303537.ch80

Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition

Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition

How to Cite

Lowsky, R. and Messner, H. (2009) Mechanisms and Treatment of Graft Failure, in Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition (eds F. R. Appelbaum, S. J. Forman, R. S. Negrin and K. G. Blume), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444303537.ch80

Editor Information

  1. 4

    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

  2. 5

    Division of Medical Oncology, University of Washington School of Medicine, Seattle, Washington, USA

  3. 6

    Department of Hematology and Hematopoietic Cell Transplantation, Duarte, California, USA

  4. 7

    Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, California, USA

  5. 8

    Division of Blood and Marrow Transplantation, Stanford University, Stanford, California, USA

  6. 9

    Division of Bone Marrow Transplantation, Department of Medicine, Stanford University, School of Medicine, Stanford, California, USA

Author Information

  1. 1

    Stanford University Medical Center, Stanford, California, USA

  2. 2

    Princess Margaret Hospital, Canada

Publication History

  1. Published Online: 5 MAR 2009
  2. Published Print: 27 FEB 2009

ISBN Information

Print ISBN: 9781405153485

Online ISBN: 9781444303537

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Keywords:

  • complications of hematopoietic cell transplantation;
  • mechanisms and treatment of graft failure;
  • factors associated with graft failure;
  • histocompatibility antigens;
  • additional factors that influence graft failure risk;
  • aplastic anemia;
  • Post-transplantation immunosuppression;
  • optimal preparative regimens;
  • donor lymphocyte infusion

Summary

This chapter contains sections titled:

  • Introduction

  • Overview of trafficking and homing of HSCs

  • Definitions

  • Incidence of graft failure

  • Causes of graft failure

  • Additional factors that influence graft failure risk

  • Strategies used for risk reduction for graft failure

  • Monitoring of graft performance

  • Interventions for graft failure

  • Summary

  • References