Chapter 84. Pharmacologic Prevention of Acute Graft-Versus-Host Disease

  1. Frederick R. Appelbaum MD Member Director Professor Head4,5,
  2. Stephen J. Forman MD Director Staff Physician6,7,
  3. Robert S. Negrin MD Professor of Medicine Chief8 and
  4. Karl G. Blume MD, FACP Emeritus Professor of Medicine8,9
  1. Nelson J. Chao MD Professor of Medicine and Imunology1 and
  2. Keith M. Sullivan MD Director2,3

Published Online: 5 MAR 2009

DOI: 10.1002/9781444303537.ch84

Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition

Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition

How to Cite

Chao, N. J. and Sullivan, K. M. (2009) Pharmacologic Prevention of Acute Graft-Versus-Host Disease, in Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition (eds F. R. Appelbaum, S. J. Forman, R. S. Negrin and K. G. Blume), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444303537.ch84

Editor Information

  1. 4

    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

  2. 5

    Division of Medical Oncology, University of Washington School of Medicine, Seattle, Washington, USA

  3. 6

    Department of Hematology and Hematopoietic Cell Transplantation, Duarte, California, USA

  4. 7

    Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, California, USA

  5. 8

    Division of Blood and Marrow Transplantation, Stanford University, Stanford, California, USA

  6. 9

    Division of Bone Marrow Transplantation, Department of Medicine, Stanford University, School of Medicine, Stanford, California, USA

Author Information

  1. 1

    Duke University Medical Center, Durham, North Carolina, USA

  2. 2

    James B Wingaarden Professor of Medicine, North Carolina, USA

  3. 3

    Long-Term Follow-up and Information Research Division of Cellular Therapy, Department of Medicine, Durham, North Carolina, USA

Publication History

  1. Published Online: 5 MAR 2009
  2. Published Print: 27 FEB 2009

ISBN Information

Print ISBN: 9781405153485

Online ISBN: 9781444303537

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Keywords:

  • alloreactivity;
  • pharmacologic prevention of acute graft-versus-host disease;
  • nonspecific immunosuppressive drugs;
  • regimens used for prophylaxis of graft-versus-host disease (GVHD);
  • suggested dose adjustments for methotrexate;
  • specific T-cell immunosuppressive drugs;
  • Sirolimus (rapamycin);
  • mycophenolate mofetil (MMF) - morpholinoethyl ester of mycophenolic acid (MPA);
  • photopheresis/pentostatin

Summary

This chapter contains sections titled:

  • Historical development

  • Pathogenesis

  • Alloreactivity

  • Predictive factors

  • Specific T-cell immunosuppressive drugs

  • Other agents

  • Conclusion

  • References