Chapter 85. T-Cell Depletion to Prevent Graft-versus-Host Disease

  1. Frederick R. Appelbaum MD Member Director Professor Head2,3,
  2. Stephen J. Forman MD Director Staff Physician4,5,
  3. Robert S. Negrin MD Professor of Medicine Chief6 and
  4. Karl G. Blume MD, FACP Emeritus Professor of Medicine6,7
  1. Robert J. Soiffer MD

Published Online: 5 MAR 2009

DOI: 10.1002/9781444303537.ch85

Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition

Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition

How to Cite

Soiffer, R. J. (2009) T-Cell Depletion to Prevent Graft-versus-Host Disease, in Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition (eds F. R. Appelbaum, S. J. Forman, R. S. Negrin and K. G. Blume), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444303537.ch85

Editor Information

  1. 2

    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

  2. 3

    Division of Medical Oncology, University of Washington School of Medicine, Seattle, Washington, USA

  3. 4

    Department of Hematology and Hematopoietic Cell Transplantation, Duarte, California, USA

  4. 5

    Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, California, USA

  5. 6

    Division of Blood and Marrow Transplantation, Stanford University, Stanford, California, USA

  6. 7

    Division of Bone Marrow Transplantation, Department of Medicine, Stanford University, School of Medicine, Stanford, California, USA

Author Information

  1. Dana Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA

Publication History

  1. Published Online: 5 MAR 2009
  2. Published Print: 27 FEB 2009

ISBN Information

Print ISBN: 9781405153485

Online ISBN: 9781444303537

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Keywords:

  • T-cell depletion to prevent graft-versus-host disease;
  • haploid identical donor transplantation;
  • TCD and reduced-intensity transplantation;
  • organ dysfunction;
  • immune reconstitution and infectious complications;
  • efforts to reduce relapse after T-cell-depleted HCT

Summary

This chapter contains sections titled:

  • Introduction

  • Early preclinical models of TCD

  • T-cell dose

  • Specificity of TCD

  • Acute GVHD

  • Chronic GVHD

  • Organ dysfunction

  • Engraftment

  • Immune reconstitution and infectious complications

  • Disease relapse

  • Efforts to reduce relapse after T-cell-depleted HCT

  • Novel approaches to graft manipulation

  • Summary

  • References