Chapter 86. Manifestations and Treatment of Acute Graft-Versus-Host Disease

  1. Frederick R. Appelbaum MD Member Director Professor Head2,3,
  2. Stephen J. Forman MD Director Staff Physician4,5,
  3. Robert S. Negrin MD Professor of Medicine Chief6 and
  4. Karl G. Blume MD, FACP Emeritus Professor of Medicine6,7
  1. Corey Cutler MD, MPH, FRCPC Assistant Professor of Medicine and
  2. Joseph H. Antin MD Professor of Medicine

Published Online: 5 MAR 2009

DOI: 10.1002/9781444303537.ch86

Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition

Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition

How to Cite

Cutler, C. and Antin, J. H. (2009) Manifestations and Treatment of Acute Graft-Versus-Host Disease, in Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition (eds F. R. Appelbaum, S. J. Forman, R. S. Negrin and K. G. Blume), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444303537.ch86

Editor Information

  1. 2

    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

  2. 3

    Division of Medical Oncology, University of Washington School of Medicine, Seattle, Washington, USA

  3. 4

    Department of Hematology and Hematopoietic Cell Transplantation, Duarte, California, USA

  4. 5

    Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, California, USA

  5. 6

    Division of Blood and Marrow Transplantation, Stanford University, Stanford, California, USA

  6. 7

    Division of Bone Marrow Transplantation, Department of Medicine, Stanford University, School of Medicine, Stanford, California, USA

Author Information

  1. Harvard Medical School, Dana Farber Cancer Institute, Boston, Massachusetts, USA

Publication History

  1. Published Online: 5 MAR 2009
  2. Published Print: 27 FEB 2009

ISBN Information

Print ISBN: 9781405153485

Online ISBN: 9781444303537

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Keywords:

  • manifestations and treatment of acute graft-versus-host disease;
  • graft composition and hematopoietic stem cell dose;
  • cytokine levels and gene polymorphisms;
  • grading and severity scores;
  • supportive care;
  • transfusion-associated GVHD;
  • lymphocyte depletion of transfused blood products

Summary

This chapter contains sections titled:

  • Background

  • Incidence and risk factors

  • Predictive assays

  • Clinical features of acute GVHD

  • Diagnosis and differential diagnosis

  • Therapy of acute GVHD

  • Special scenarios

  • Conclusion

  • References