Chapter 87. Chronic Graft-versus-Host Disease: Clinical Manifestations and Therapy

  1. Frederick R. Appelbaum MD Member Director Professor Head3,4,
  2. Stephen J. Forman MD Director Staff Physician5,6,
  3. Robert S. Negrin MD Professor of Medicine Chief7 and
  4. Karl G. Blume MD, FACP Emeritus Professor of Medicine7,8
  1. Steven Z. Pavletic MD1 and
  2. Georgia B. Vogelsang MD2

Published Online: 5 MAR 2009

DOI: 10.1002/9781444303537.ch87

Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition

Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition

How to Cite

Pavletic, S. Z. and Vogelsang, G. B. (2009) Chronic Graft-versus-Host Disease: Clinical Manifestations and Therapy, in Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition (eds F. R. Appelbaum, S. J. Forman, R. S. Negrin and K. G. Blume), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444303537.ch87

Editor Information

  1. 3

    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

  2. 4

    Division of Medical Oncology, University of Washington School of Medicine, Seattle, Washington, USA

  3. 5

    Department of Hematology and Hematopoietic Cell Transplantation, Duarte, California, USA

  4. 6

    Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, California, USA

  5. 7

    Division of Blood and Marrow Transplantation, Stanford University, Stanford, California, USA

  6. 8

    Division of Bone Marrow Transplantation, Department of Medicine, Stanford University, School of Medicine, Stanford, California, USA

Author Information

  1. 1

    Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA

  2. 2

    The Johns Hopkins University, Sidney Kimmel Cancer Center, Baltimore, Maryland, USA

Publication History

  1. Published Online: 5 MAR 2009
  2. Published Print: 27 FEB 2009

ISBN Information

Print ISBN: 9781405153485

Online ISBN: 9781444303537

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Keywords:

  • chronic graft-versus-host disease: clinical manifestations and therapy;
  • pathogenesis in humans;
  • prognostic factors for outcomes in patients with chronic GVHD;
  • clinical manifestations and diagnosis of chronic GVHD;
  • organ-specific manifestations;
  • acute and chronic graft-versus-host disease (GVHD);
  • hematopoietic and immune systems;
  • classification and staging of chronic GVHD;
  • ancillary therapy and supportive care

Summary

This chapter contains sections titled:

  • Introduction

  • Risk factors for onset of chronic GVHD

  • Prognostic factors for outcomes in patients with chronic GVHD

  • Pathogenesis in humans

  • Clinical manifestations and diagnosis of chronic GVHD

  • Histopathology and diagnosis of chronic GVHD

  • Classification and staging of chronic GVHD

  • Measuring response in therapeutic clinical trials

  • Prevention

  • Treatment

  • QOL and other health-related outcomes in chronic GVHD

  • Graft-versus-leukemia effect

  • Future directions

  • Acknowledgment

  • References