Chapter 9. Mesenchymal Stromal Cells and Hematopoietic Cell Transplantation

  1. Frederick R. Appelbaum MD Member Director Professor Head2,3,
  2. Stephen J. Forman MD Director Staff Physician4,5,
  3. Robert S. Negrin MD Professor of Medicine Chief6 and
  4. Karl G. Blume MD, FACP Emeritus Professor of Medicine6,7
  1. Edwin M. Horwitz MD, MS

Published Online: 5 MAR 2009

DOI: 10.1002/9781444303537.ch9

Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition

Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition

How to Cite

Horwitz, E. M. (2009) Mesenchymal Stromal Cells and Hematopoietic Cell Transplantation, in Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, Fourth Edition (eds F. R. Appelbaum, S. J. Forman, R. S. Negrin and K. G. Blume), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444303537.ch9

Editor Information

  1. 2

    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

  2. 3

    Division of Medical Oncology, University of Washington School of Medicine, Seattle, Washington, USA

  3. 4

    Department of Hematology and Hematopoietic Cell Transplantation, Duarte, California, USA

  4. 5

    Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, California, USA

  5. 6

    Division of Blood and Marrow Transplantation, Stanford University, Stanford, California, USA

  6. 7

    Division of Bone Marrow Transplantation, Department of Medicine, Stanford University, School of Medicine, Stanford, California, USA

Author Information

  1. Children's Hospital of Philadelphia, Abramson Research Center, Philadelphia, Pennsylvania, USA

Publication History

  1. Published Online: 5 MAR 2009
  2. Published Print: 27 FEB 2009

ISBN Information

Print ISBN: 9781405153485

Online ISBN: 9781444303537

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Keywords:

  • mesenchymal stromal cells and hematopoietic cell transplantation;
  • hematopoietic cell transplantation (HCT);
  • marrow mesenchymal stromal cells (MSCs);
  • MSCs with remarkable capacity for ex vivo expansion;
  • in vitro differentiation potential;
  • immunobiology;
  • T lymphocytes;
  • highly complex biology of MSCs undoubtedly fostering clinical applications

Summary

This chapter contains sections titled:

  • Introduction

  • Brief history of MSCs

  • Nomenclature

  • Biology

  • Immunobiology

  • Physiologic role of MSCs

  • Clinical applications

  • Future considerations

  • References