Chapter 11. Standardization of D-Dimer Testing

  1. Steve Kitchen PhD Clinical Scientist Scientific Director3,4,5,
  2. John D. Olson MD, PhD Professor Vice Chair for Clinical Affairs6,
  3. F. Eric Preston MD, FRCPath, FRCP Emeritus Professor of Hematology Director7,8
  1. G. Reber PhD1,
  2. P. de Moerloose MD2

Published Online: 4 MAR 2009

DOI: 10.1002/9781444303575.ch11

Book Title

Quality in Laboratory Hemostasis and Thrombosis

Quality in Laboratory Hemostasis and Thrombosis

Additional Information

How to Cite

Reber, G. and de Moerloose, P. (2009) Standardization of D-Dimer Testing, in Quality in Laboratory Hemostasis and Thrombosis (eds S. Kitchen, J. D. Olson and F. E. Preston), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444303575.ch11

Editor Information

  1. 3

    Sheffield Hemophilia and Thrombosis Centre, Royal Hallamshire Hospital, Sheffield, UK

  2. 4

    UK National External Quality Assessment Scheme (EQAS) for Blood Coagulation, Sheffield, UK

  3. 5

    WHO and WFH International External Quality Assessment Programs for Blood Coagulation, Sheffield, UK

  4. 6

    Department of Pathology, University of Texas Health Science Center, San Antonio, Texas, USA

  5. 7

    University of Sheffield, Sheffield, UK

  6. 8

    WHO and WFH International External Quality Assessment Programs for Blood Coagulation, Rutledge Mews, Sheffield, UK

Author Information

  1. 1

    Hemostasis Unit, Department of Internal Medicine, University Hospital and Faculty of Medicine, Geneva, Switzerland

  2. 2

    Hemostasis Unit, University Hospital Geneva, Geneva, Switzerland

Publication History

  1. Published Online: 4 MAR 2009
  2. Published Print: 19 DEC 2008

ISBN Information

Print ISBN: 9781405168038

Online ISBN: 9781444303575

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CHAPTER TOOLS

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Keywords:

  • D-dimer measurement - indicator of coagulation activation and fibrin digestion;
  • standardization of D-dimer testing;
  • harmonization of D-dimer assays;
  • method-specific consensus values;
  • lack of standardization of D-dimer results - misleading in daily laboratory and clinical practice;
  • harmonization of D-dimer results and uniformity to D-dimer contribution in DIC scores

Summary

This chapter contains sections titled:

  • Heterogeneity of D-dimer containing fragments

  • Specificity of monoclonal antibodies directed to D-dimer motif

  • Calibrators for D-dimer assays

  • Standardization of D-dimer assays

  • Harmonization of D-dimer assays

  • Problems in daily practice

  • Conclusions

  • References

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