Chapter 12. Diagnostic Assessment of Platelet Function

  1. Steve Kitchen PhD Clinical Scientist Scientific Director2,3,4,
  2. John D. Olson MD, PhD Professor Vice Chair for Clinical Affairs5,
  3. F. Eric Preston MD, FRCPath, FRCP Emeritus Professor of Hematology Director6,7
  1. P. Nurden MD, PhD,
  2. A. Nurden PhD

Published Online: 4 MAR 2009

DOI: 10.1002/9781444303575.ch12

Book Title

Quality in Laboratory Hemostasis and Thrombosis

Quality in Laboratory Hemostasis and Thrombosis

Additional Information

How to Cite

Nurden, P. and Nurden, A. (2009) Diagnostic Assessment of Platelet Function, in Quality in Laboratory Hemostasis and Thrombosis (eds S. Kitchen, J. D. Olson and F. E. Preston), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444303575.ch12

Editor Information

  1. 2

    Sheffield Hemophilia and Thrombosis Centre, Royal Hallamshire Hospital, Sheffield, UK

  2. 3

    UK National External Quality Assessment Scheme (EQAS) for Blood Coagulation, Sheffield, UK

  3. 4

    WHO and WFH International External Quality Assessment Programs for Blood Coagulation, Sheffield, UK

  4. 5

    Department of Pathology, University of Texas Health Science Center, San Antonio, Texas, USA

  5. 6

    University of Sheffield, Sheffield, UK

  6. 7

    WHO and WFH International External Quality Assessment Programs for Blood Coagulation, Rutledge Mews, Sheffield, UK

Author Information

  1. Centre de Référence des Pathologies Plaquettaires, Plateforme Technologique d'Innovation Biomédicale, Hôpital Xavier Arnozan, Pessac, France

Publication History

  1. Published Online: 4 MAR 2009
  2. Published Print: 19 DEC 2008

ISBN Information

Print ISBN: 9781405168038

Online ISBN: 9781444303575

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CHAPTER TOOLS

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Keywords:

  • platelet function analysis;
  • GPIb-IX-V complex binds to multimers of von Willebrand factor (VWF);
  • skin bleeding time (BT);
  • platelet counting with hematology analyzers;
  • assessing residual prothrombin (PT) levels;
  • Platelet Function Analyzer-100 (PFA-100) closure time (CT) and high shear-dependent platelet function;
  • point-of-care tests;
  • platelet aggregometry;
  • flow cytometry (FC) and functional status of platelets;
  • proteomics and genomics in studying platelets

Summary

This chapter contains sections titled:

  • Bleeding time

  • Prothrombin consumption

  • Platelet counting and morphology

  • Platelet Function Analyzer-100

  • Point-of-care tests

  • Platelet aggregometry

  • Platelet secretion

  • Flow cytometry

  • Clot retraction

  • Signaling pathways

  • In vitro studies on thrombus formation

  • New technologies

  • References

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