Chapter 13. Laboratory Evaluation of von Willebrand Disease: Phenotypic Analysis

  1. Steve Kitchen PhD Clinical Scientist Scientific Director2,3,4,
  2. John D. Olson MD, PhD Professor Vice Chair for Clinical Affairs5 and
  3. F. Eric Preston MD, FRCPath, FRCP Emeritus Professor of Hematology Director6,7
  1. E. J. Favaloro PhD

Published Online: 4 MAR 2009

DOI: 10.1002/9781444303575.ch13

Quality in Laboratory Hemostasis and Thrombosis

Quality in Laboratory Hemostasis and Thrombosis

How to Cite

Favaloro, E. J. (2009) Laboratory Evaluation of von Willebrand Disease: Phenotypic Analysis, in Quality in Laboratory Hemostasis and Thrombosis (eds S. Kitchen, J. D. Olson and F. E. Preston), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444303575.ch13

Editor Information

  1. 2

    Sheffield Hemophilia and Thrombosis Centre, Royal Hallamshire Hospital, Sheffield, UK

  2. 3

    UK National External Quality Assessment Scheme (EQAS) for Blood Coagulation, Sheffield, UK

  3. 4

    WHO and WFH International External Quality Assessment Programs for Blood Coagulation, Sheffield, UK

  4. 5

    Department of Pathology, University of Texas Health Science Center, San Antonio, Texas, USA

  5. 6

    University of Sheffield, Sheffield, UK

  6. 7

    WHO and WFH International External Quality Assessment Programs for Blood Coagulation, Rutledge Mews, Sheffield, UK

Author Information

  1. Department of Hematology, Institute of Clinical Pathology and Medical Research, Westmead Hospital, NSW, Australia

Publication History

  1. Published Online: 4 MAR 2009
  2. Published Print: 19 DEC 2008

ISBN Information

Print ISBN: 9781405168038

Online ISBN: 9781444303575

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Keywords:

  • von Willebrand disease and von Willebrand factor (VWF);
  • Von Willebrand disease (VWD) - common inherited bleeding ailment;
  • fundamental problems with phenotypic evaluation of VWD;
  • phenotypic assays used in VWD diagnosis;
  • gel eletrophoresis procedure identifying VWF of differing molecular weights;
  • diagnostic laboratory process for VWD;
  • DDAVP challenge or factor concentrate pharmacokinetics (PK) in VWD diagnosis

Summary

This chapter contains sections titled:

  • Background

  • Phenotypic assays used in the diagnosis of VWD

  • A diagnostic laboratory process for VWD

  • Recommendations and conclusions

  • Acknowledgments

  • References