Chapter 15. Dilemmas in Heritable Thrombophilia Testing

  1. Steve Kitchen PhD Clinical Scientist Scientific Director3,4,5,
  2. John D. Olson MD, PhD Professor Vice Chair for Clinical Affairs6 and
  3. F. Eric Preston MD, FRCPath, FRCP Emeritus Professor of Hematology Director7,8
  1. I. D. Walker MD1 and
  2. I. Jennings PhD, CSci2

Published Online: 4 MAR 2009

DOI: 10.1002/9781444303575.ch15

Quality in Laboratory Hemostasis and Thrombosis

Quality in Laboratory Hemostasis and Thrombosis

How to Cite

Walker, I. D. and Jennings, I. (2008) Dilemmas in Heritable Thrombophilia Testing, in Quality in Laboratory Hemostasis and Thrombosis (eds S. Kitchen, J. D. Olson and F. E. Preston), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444303575.ch15

Editor Information

  1. 3

    Sheffield Hemophilia and Thrombosis Centre, Royal Hallamshire Hospital, Sheffield, UK

  2. 4

    UK National External Quality Assessment Scheme (EQAS) for Blood Coagulation, Sheffield, UK

  3. 5

    WHO and WFH International External Quality Assessment Programs for Blood Coagulation, Sheffield, UK

  4. 6

    Department of Pathology, University of Texas Health Science Center, San Antonio, Texas, USA

  5. 7

    University of Sheffield, Sheffield, UK

  6. 8

    WHO and WFH International External Quality Assessment Programs for Blood Coagulation, Rutledge Mews, Sheffield, UK

Author Information

  1. 1

    Department of Hematology, Glasgow Royal Infirmary, Glasgow, UK

  2. 2

    UK NEQAS (Blood Coagulation), Rutledge Mews, Sheffield, UK

Publication History

  1. Published Online: 4 MAR 2009
  2. Published Print: 19 DEC 2008

ISBN Information

Print ISBN: 9781405168038

Online ISBN: 9781444303575

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Keywords:

  • heritable thrombophilia testing;
  • UK NEQAS for blood coagulation exercise;
  • Testing for APC resistance;
  • prothrombin G20210A mutation;
  • physiologic and pathologic variability;
  • inter-method variability for protein S activity assays

Summary

This chapter contains sections titled:

  • What to include in the thrombophilia screen

  • Which methods?

  • What samples and when?

  • Interpreting the results

  • Who should be tested?

  • References