Chapter 18. Monitoring Oral Anticoagulant Therapy

  1. Steve Kitchen PhD Clinical Scientist Scientific Director2,3,4,
  2. John D. Olson MD, PhD Professor Vice Chair for Clinical Affairs5 and
  3. F. Eric Preston MD, FRCPath, FRCP Emeritus Professor of Hematology Director6,7
  1. A. Tripodi PhD

Published Online: 4 MAR 2009

DOI: 10.1002/9781444303575.ch18

Quality in Laboratory Hemostasis and Thrombosis

Quality in Laboratory Hemostasis and Thrombosis

How to Cite

Tripodi, A. (2009) Monitoring Oral Anticoagulant Therapy, in Quality in Laboratory Hemostasis and Thrombosis (eds S. Kitchen, J. D. Olson and F. E. Preston), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444303575.ch18

Editor Information

  1. 2

    Sheffield Hemophilia and Thrombosis Centre, Royal Hallamshire Hospital, Sheffield, UK

  2. 3

    UK National External Quality Assessment Scheme (EQAS) for Blood Coagulation, Sheffield, UK

  3. 4

    WHO and WFH International External Quality Assessment Programs for Blood Coagulation, Sheffield, UK

  4. 5

    Department of Pathology, University of Texas Health Science Center, San Antonio, Texas, USA

  5. 6

    University of Sheffield, Sheffield, UK

  6. 7

    WHO and WFH International External Quality Assessment Programs for Blood Coagulation, Rutledge Mews, Sheffield, UK

Author Information

  1. Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine, University School of Medicine and IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation, Milan, Italy

Publication History

  1. Published Online: 4 MAR 2009
  2. Published Print: 19 DEC 2008

ISBN Information

Print ISBN: 9781405168038

Online ISBN: 9781444303575

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Keywords:

  • Vitamin K antagonists (VKA) - oral anticoagulants for venous thromboembolism;
  • thromboplastin calibration;
  • oral anticoagulant therapy;
  • IRPs crucial for model of WHO calibration;
  • conversion of PT into INR and issues affecting results;
  • Mean normal prothrombin time;
  • International Sensitivity Index;
  • “model for end-stage liver disease (MELD)” score;
  • implementation of INR

Summary

This chapter contains sections titled:

  • Thromboplastin calibration

  • Hierarchy of WHO International Reference Preparations

  • Conversion of PT into INR and issues affecting results

  • Limits of the INR

  • Implementation of the INR

  • Conclusions and future directions

  • References