Chapter 4. Sample Integrity and Preanalytical Variables

  1. Steve Kitchen PhD Clinical Scientist Scientific Director2,3,4,
  2. John D. Olson MD, PhD Professor Vice Chair for Clinical Affairs5 and
  3. F. Eric Preston MD, FRCPath, FRCP Emeritus Professor of Hematology Director6,7
  1. D. M. Adcock MD

Published Online: 4 MAR 2009

DOI: 10.1002/9781444303575.ch4

Quality in Laboratory Hemostasis and Thrombosis

Quality in Laboratory Hemostasis and Thrombosis

How to Cite

Adcock, D. M. (2008) Sample Integrity and Preanalytical Variables, in Quality in Laboratory Hemostasis and Thrombosis (eds S. Kitchen, J. D. Olson and F. E. Preston), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444303575.ch4

Editor Information

  1. 2

    Sheffield Hemophilia and Thrombosis Centre, Royal Hallamshire Hospital, Sheffield, UK

  2. 3

    UK National External Quality Assessment Scheme (EQAS) for Blood Coagulation, Sheffield, UK

  3. 4

    WHO and WFH International External Quality Assessment Programs for Blood Coagulation, Sheffield, UK

  4. 5

    Department of Pathology, University of Texas Health Science Center, San Antonio, Texas, USA

  5. 6

    University of Sheffield, Sheffield, UK

  6. 7

    WHO and WFH International External Quality Assessment Programs for Blood Coagulation, Rutledge Mews, Sheffield, UK

Author Information

  1. Esoterix Coagulation, Englewood, Colorado, USA

Publication History

  1. Published Online: 4 MAR 2009
  2. Published Print: 19 DEC 2008

ISBN Information

Print ISBN: 9781405168038

Online ISBN: 9781444303575

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Keywords:

  • sample integrity and preanalytic variables;
  • Laboratory testing - integral component of clinical decision-making;
  • sample acquisition (specimen collection);
  • prothrombin time (PT) and activated partial thromboplastin time (aPTT);
  • sodium citrate collection tubes;
  • whole blood specimen transportation to laboratory;
  • stability and storage of plasma samples;
  • common sources of error;
  • ideal samples for hemostasis testing

Summary

This chapter contains sections titled:

  • Sample acquisition (specimen collection)

  • Transportation of whole blood specimens to the laboratory

  • Specimen processing

  • Stability and storage of plasma samples

  • Controlled thawing of frozen plasma samples

  • Conclusions

  • References